Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
General Medication Fact Sheet for Agrylin
| Field | Information |
|---|---|
| Medication Name | Agrylin |
| Generic Name | Anagrelide |
| Boxed/Label Warning | May cause serious cardiovascular side effects, including palpitations, arrhythmias, heart failure, and pulmonary hypertension. Use with caution in patients with known cardiovascular disease. |
| Purpose | To reduce elevated platelet counts in essential thrombocythemia. |
| Mechanism of Action | Inhibits platelet production by interfering with megakaryocyte maturation. |
| Dosage Forms | Oral capsules |
| Available Strengths | 0.5 mg, 1 mg |
| Dosage Frequency | Typically twice daily, or as directed by a healthcare provider. |
| Common Side Effects | Headache, edema, palpitations, nausea, diarrhea, fatigue. |
| Serious Side Effects | Cardiovascular events (heart failure, arrhythmias), pulmonary hypertension, bleeding, anemia. |
| Drug Interactions | Aspirin, other antiplatelet agents (e.g., clopidogrel), anticoagulants (e.g., warfarin), CYP1A2 inhibitors (e.g., fluvoxamine), omeprazole. |
| Important Notes | Regular monitoring of blood counts and cardiovascular function is necessary. Use caution in patients with hepatic or renal impairment. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Hydroxyurea, Interferon alfa, Aspirin (low-dose) |
Agrylin Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Hydroxyurea | Inhibits DNA synthesis, reducing cell proliferation, including platelets. | A common first-line treatment for essential thrombocythemia. |
| Aspirin (low-dose) | Inhibits platelet aggregation. | Used to reduce the risk of thrombosis in patients with essential thrombocythemia, typically in combination with other treatments. |
Agrylin Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Cardiovascular events (heart failure, arrhythmias) |
| Edema | Pulmonary hypertension |
| Palpitations | Bleeding |
| Nausea | Anemia |
| Diarrhea | Severe allergic reactions |
| Fatigue | Liver problems |
Agrylin Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Essential Thrombocythemia | 0.5 mg twice daily | Individualized; increase gradually to the lowest dose needed to maintain platelet count within normal range. Typically 1.5 to 10 mg daily, divided into multiple doses. | Take as directed by your healthcare provider. Monitor platelet counts regularly. |
