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General Medication Fact Sheet for Amgevita
| Field | Information |
|---|---|
| Medication Name | Amgevita |
| Generic Name | Adalimumab |
| Purpose | Treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, and uveitis |
| Mechanism of Action | Tumor necrosis factor (TNF) blocker; binds to TNF-alpha, preventing it from activating TNF receptors |
| Dosage Forms | Subcutaneous injection (prefilled syringe or pen) |
| Available Strengths | 40 mg/0.8 mL, 20 mg/0.4 mL |
| Dosage Frequency | Varies based on condition; typically every other week or weekly |
| Common Side Effects | Injection site reactions (pain, redness, swelling), upper respiratory infections, headache, rash |
| Serious Side Effects | Serious infections (e.g., tuberculosis, fungal infections), lymphoma and other cancers, heart failure, nervous system disorders, allergic reactions |
| Drug Interactions | Other TNF blockers (e.g., etanercept, infliximab), abatacept, anakinra, live vaccines, certain immunosuppressants (e.g., azathioprine, methotrexate) |
| Important Notes | Increased risk of infections; get tested for tuberculosis before starting; avoid live vaccines; report any signs of infection immediately |
| Storage | Store in the refrigerator at 36°F to 46°F (2°C to 8°C); protect from light; do not freeze |
| Missed Dose | Inject the missed dose as soon as you remember, then continue with your regular schedule |
| Alternatives | Humira (adalimumab), Enbrel (etanercept), Remicade (infliximab), Cimzia (certolizumab pegol), Simponi (golimumab) |
Amgevita Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Humira (adalimumab) | TNF-alpha inhibitor | Biosimilar to Amgevita. |
| Enbrel (etanercept) | TNF-alpha inhibitor | Binds to TNF, preventing it from interacting with cell surface receptors. |
| Remicade (infliximab) | TNF-alpha inhibitor | Administered intravenously; binds to TNF-alpha. |
| Cimzia (certolizumab pegol) | TNF-alpha inhibitor | PEGylated TNF-alpha inhibitor. |
| Simponi (golimumab) | TNF-alpha inhibitor | Human TNF-alpha inhibitor. |
Amgevita Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Injection site reactions (pain, redness, swelling) | Serious infections (e.g., tuberculosis, pneumonia) |
| Upper respiratory infections (e.g., sinusitis, pharyngitis) | Lymphoma and other cancers |
| Headache | Heart failure (new or worsening) |
| Rash | Nervous system disorders (e.g., multiple sclerosis-like symptoms) |
| Nausea | Allergic reactions (e.g., hives, difficulty breathing) |
Amgevita Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Rheumatoid Arthritis | 40 mg every other week | 40 mg every other week | Administered as a subcutaneous injection. |
| Psoriatic Arthritis | 40 mg every other week | 40 mg every other week | Administered as a subcutaneous injection. |
| Ankylosing Spondylitis | 40 mg every other week | 40 mg every other week | Administered as a subcutaneous injection. |
| Crohn’s Disease | 160 mg initially, followed by 80 mg two weeks later | 40 mg every other week | Administered as a subcutaneous injection. |
| Ulcerative Colitis | 160 mg initially, followed by 80 mg two weeks later | 40 mg every other week | Administered as a subcutaneous injection. |
| Plaque Psoriasis | 80 mg initially | 40 mg every other week | Administered as a subcutaneous injection. |
| Hidradenitis Suppurativa | 160 mg initially, followed by 80 mg two weeks later | 40 mg weekly or 80 mg every other week | Administered as a subcutaneous injection. |
| Uveitis | 80 mg initially | 40 mg every other week | Administered as a subcutaneous injection. |
