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Arthrotec (Diclofenac,Misoprostol)
| Diclofenac Sodium / Misoprostol (Generic) Diclofenac Sodium, Misoprostol | ||||||
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Shipped from Canada | ||||||
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| Select product strength & quantity:
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| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Arthrotec
| Field | Information |
|---|---|
| Medication Name | Arthrotec |
| Generic Name | Diclofenac/Misoprostol |
| Boxed/Label Warning | NSAIDs may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. Misoprostol can cause abortion, premature birth, or birth defects if administered to pregnant women. |
| Purpose | To relieve the pain and inflammation of arthritis while helping to prevent stomach ulcers that can be caused by NSAIDs. |
| Mechanism of Action | Diclofenac inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis, thereby reducing pain and inflammation. Misoprostol is a synthetic prostaglandin E1 analog that protects the stomach lining. |
| Dosage Forms | Oral tablets |
| Available Strengths | 50 mg Diclofenac/200 mcg misoprostol, 75 mg Diclofenac/200 mcg misoprostol |
| Dosage Frequency | Typically two to three times daily, or as directed by a healthcare provider. |
| Common Side Effects | Abdominal pain, diarrhea, nausea, flatulence, headache. |
| Serious Side Effects | Gastrointestinal bleeding, ulceration, perforation, cardiovascular events, severe allergic reactions. |
| Drug Interactions | Other NSAIDs, aspirin, anticoagulants (e.g., warfarin), certain antidepressants (SSRIs), ACE inhibitors, diuretics. |
| Important Notes | Take with food and a full glass of water. Avoid use in pregnant women. Monitor for signs of gastrointestinal bleeding. Consult a doctor if you have heart, liver, or kidney problems. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Diclofenac, Celecoxib, Naproxen, Ibuprofen. Consider a PPI (Proton Pump Inhibitor) alongside an NSAID for gastroprotection. |
Arthrotec Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Diclofenac (Voltaren) | Non-selective COX inhibitor | Does not contain a gastroprotective agent like misoprostol. Requires monitoring for GI side effects. |
| Celecoxib (Celebrex) | Selective COX-2 inhibitor | May have a lower risk of gastrointestinal side effects compared to non-selective NSAIDs, but increased cardiovascular risk may be a concern in some patients. |
| Naproxen (Aleve) | Non-selective COX inhibitor | Increased risk of GI side effects, may be prescribed with a PPI. |
| Ibuprofen (Advil, Motrin) | Non-selective COX inhibitor | Commonly used for mild to moderate pain relief; may be prescribed with a PPI for long-term use. |
Arthrotec Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Abdominal pain | Gastrointestinal bleeding |
| Diarrhea | Ulceration and perforation of stomach or intestines |
| Nausea | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Flatulence | Heart problems (increased risk of heart attack or stroke) |
| Headache | Kidney problems |
Arthrotec Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Osteoarthritis | 50 mg Diclofenac/200 mcg misoprostol | 50 mg Diclofenac/200 mcg misoprostol two to three times daily | Take with food and a full glass of water. |
| Rheumatoid Arthritis | 50 mg Diclofenac/200 mcg misoprostol | 50 mg Diclofenac/200 mcg misoprostol two to three times daily | Take with food and a full glass of water. |
| Pain and Inflammation | 50 mg Diclofenac/200 mcg misoprostol | 50 mg Diclofenac/200 mcg misoprostol two to three times daily | Take with food and a full glass of water. |
Arthrotec Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 – $200 (varies by plan) |
| Without Insurance (U.S.) | $525.84 |
| From Canada | $87.95 |
