Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Description
General Medication Fact Sheet for Besponsa
| Field | Information |
|---|---|
| Medication Name | Besponsa |
| Generic Name | Inotuzumab Ozogamicin |
| Boxed/Label Warning | Severe hepatotoxicity, including hepatic veno-occlusive disease (VOD); increased risk of post-hematopoietic stem cell transplant (HSCT) VOD; myelosuppression; infusion-related reactions; and prolonged QT interval. |
| Purpose | Treatment of relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL) in adults. |
| Mechanism of Action | An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting CD22, a protein found on ALL cells, linked to calicheamicin, a cytotoxic agent. Upon binding to CD22, Besponsa is internalized into the cell, releasing calicheamicin, which induces DNA double-strand breaks, resulting in cell death. |
| Dosage Forms | Lyophilized powder for intravenous infusion |
| Available Strengths | 1 mg |
| Dosage Frequency | Administered as an intravenous infusion on days 1, 8, and 15 of a 21- to 28-day cycle. |
| Common Side Effects | Fever, nausea, headache, neutropenia, thrombocytopenia, infection, fatigue, abdominal pain. |
| Serious Side Effects | Hepatic veno-occlusive disease (VOD), myelosuppression (including neutropenia, thrombocytopenia, anemia), infusion-related reactions, QT prolongation, tumor lysis syndrome. |
| Drug Interactions | Drugs that inhibit or induce CYP3A4 or P-gp may alter inotuzumab ozogamicin exposure. Avoid concomitant use with strong CYP3A4 inhibitors. Exercise caution with QT-prolonging drugs. |
| Important Notes | Premedication for infusion-related reactions is recommended. Monitor for signs and symptoms of VOD, myelosuppression, and QT prolongation. Consider dose modifications or discontinuation for severe toxicities. |
| Storage | Store vials in a refrigerator at 2°C to 8°C (36°F to 46°F) until time of use. Protect from light. |
| Missed Dose | Contact your healthcare provider immediately for instructions if you miss a scheduled infusion. Do not attempt to adjust the dosing schedule on your own. |
| Alternatives | Blinatumomab (Blincyto), Clofarabine, Chemotherapy regimens (e.g., Hyper-CVAD), Stem cell transplant. |
Besponsa Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Blinatumomab (Blincyto) | Bispecific T-cell engager (BiTE) antibody that binds to CD19 on leukemia cells and CD3 on T cells, activating T cells to kill leukemia cells. | Indicated for relapsed or refractory B-cell precursor ALL. |
| Clofarabine | Purine nucleoside antimetabolite that inhibits DNA synthesis and induces cell death. | Used in the treatment of relapsed or refractory ALL in pediatric and adult patients. |
| Chemotherapy regimens (e.g., Hyper-CVAD) | Combination chemotherapy regimens using various cytotoxic agents. | Traditional treatment approach for ALL, often used in combination with other therapies. |
| Stem cell transplant | Procedure to replace damaged or destroyed bone marrow with healthy stem cells. | May be considered for patients with relapsed or refractory ALL after achieving remission. |
Besponsa Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Fever | Hepatic veno-occlusive disease (VOD) |
| Nausea | Myelosuppression (Neutropenia, Thrombocytopenia, Anemia) |
| Headache | Infusion-related reactions |
| Fatigue | QT prolongation |
| Abdominal pain | Tumor lysis syndrome |
| Infection | Hemorrhage |
Besponsa Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Relapsed or Refractory B-cell ALL | 1.8 mg/m² | 1.8 mg/m² on days 1, 8, and 15 of each 21- to 28-day cycle. | Administer as an intravenous infusion over 1 hour. Premedicate for infusion-related reactions. Dosing adjustments may be necessary based on toxicities. Consult with a healthcare professional for personalized dosage adjustments. |
Besponsa Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $5,000 – $15,000 |
| Without Insurance (U.S.) | $17,000 – $18,000 |
| From Canada | $22689.20 |
Why Americans Buy Besponsa from Canada Pharmacy Store?
Why Americans Buy Besponsa from Canada Pharmacy Store?
Americans have trouble affording Besponsa due to numerous factors—but at Canada Pharmacy Store, we offer a safe, affordable alternative. That’s why thousands of Americans trust us to fill their prescriptions with real savings and real service.
Big Savings on U.S. Medications
Our customers save up to 80% on their Besponsa prescriptions compared to U.S. pharmacy prices by ordering through licensed Canadian and international pharmacies.
Free Prescription Transfers
We make it easy! Our pharmacy team can transfer your Besponsa prescriptions directly from your doctor or local pharmacy – completely free of charge.
Direct Access to Experts
Our licensed pharmacists are available to support you, answer your questions, and help ensure you’re confident in your treatment.
Referral Discounts
Spread the word—when you refer friends or family, you both save. It’s our way of saying thanks.
Discreet U.S. Shipping
All orders are packaged discreetly and shipped securely to your U.S. address, with your privacy and safety as top priorities.
Trusted by Americans Nationwide
With years of experience and verified medication sources, we’ve become a go-to solution for Americans looking to cut costs without compromising care.
How to Order Besponsa Online
How to Order Besponsa Online
Step 1
Select Your Prescribed Besponsa Dosage
Choose the strength and quantity as directed by your healthcare provider and add it to your cart.
Step 2
Proceed Through Secure Checkout
Follow the steps to complete your order and provide necessary shipping and payment details.
Step 3
Upload Your Besponsa Prescription
Submit a prescription from a licensed U.S. healthcare provider that matches your order.
At Canada Pharmacy Store, patient safety comes first. We strictly comply with prescription regulations and do not ship any medication without a valid, verifiable prescription. Orders may be declined if a prescription appears falsified or altered in any way. We take these precautions to protect your health and ensure lawful, responsible practices.
Guarantee
Our Guarantee When You Buy Besponsa Through Canada Pharmacy Store
At Canada Pharmacy Store, your safety and satisfaction are our top priorities. We supply only authentic, high-quality medications by working exclusively with licensed Canadian pharmacies and trusted international partners. Every order is filled in accordance with strict regulatory standards and includes medication that’s fully approved by Health Canada or other recognized health authorities such as the MHRA (UK), HSA (Singapore), and the Pharmacy Board of Mauritius.
The Besponsa you receive is the same active medication as what’s available in the U.S.—the only difference is the packaging, which reflects its country of origin. Our licensed healthcare professionals review each order carefully to ensure it matches your prescription exactly.
To get Besponsa at a lower price, simply place your order above or give us a call at 1-888-903-2240
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