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Brilinta (Ticagrelor)
| Brilinta Ticagrelor | ||||||
Shipped from United Kingdom | ||||||
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| Brilinta Ticagrelor | ||||||
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Shipped from Mauritius | ||||||
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General Medication Fact Sheet for Brilinta
| Field | Information |
|---|---|
| Medication Name | Brilinta |
| Generic Name | Ticagrelor |
| Boxed/Label Warning | Significant bleeding risk, reduced effectiveness with high-dose aspirin (greater than 100mg daily). |
| Purpose | Reduces the risk of cardiovascular events (e.g., heart attack, stroke) in patients with acute coronary syndrome (ACS) or a history of heart attack. |
| Mechanism of Action | A platelet aggregation inhibitor that reversibly binds to the P2Y12 ADP receptor on platelets, preventing activation and aggregation. |
| Dosage Forms | Oral tablets |
| Available Strengths | 90 mg, 60 mg |
| Dosage Frequency | Typically twice daily |
| Common Side Effects | Shortness of breath (dyspnea), bleeding (nosebleeds, bruising), increased uric acid levels. |
| Serious Side Effects | Significant bleeding (including intracranial hemorrhage), severe allergic reactions, slow heart rate (bradycardia). |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole), strong CYP3A4 inducers (e.g., rifampin), aspirin (doses above 100mg), opioids. |
| Important Notes | Do not stop taking Brilinta without talking to your doctor, as this can increase your risk of blood clots. Report any unusual bleeding or bruising to your doctor immediately. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Clopidogrel (Plavix), Prasugrel (Effient), Aspirin. |
Brilinta Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Clopidogrel (Plavix) | P2Y12 ADP receptor inhibitor (prodrug) | Requires metabolic activation; may be less effective in some individuals. |
| Prasugrel (Effient) | P2Y12 ADP receptor inhibitor (prodrug) | More potent than Clopidogrel, but may have a higher risk of bleeding. |
| Aspirin | COX-1 inhibitor | Often used in combination with P2Y12 inhibitors for antiplatelet therapy. |
Brilinta Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Shortness of breath (dyspnea) | Significant bleeding (e.g., intracranial hemorrhage) |
| Bleeding (nosebleeds, bruising) | Severe allergic reactions (e.g., anaphylaxis) |
| Increased uric acid levels | Slow heart rate (bradycardia) |
| Dizziness | Thrombotic Thrombocytopenic Purpura (TTP) – rare |
Brilinta Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Acute Coronary Syndrome (ACS) | 180 mg loading dose | 90 mg twice daily | Administer with aspirin (75-100 mg daily), unless contraindicated. |
| History of Heart Attack (beyond 1 year) | N/A | 60 mg twice daily | Administer with aspirin (75-100 mg daily), unless contraindicated. |
Brilinta Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30–$100 |
| Without Insurance (U.S.) | $454.76 |
| From Canada | $37.95 |
