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General Medication Fact Sheet for Brimonidine
| Field | Information |
|---|---|
| Generic Name | Brimonidine |
| Brand Name Versions | Alphagan P, Lumigan |
| Purpose | To lower intraocular (eye) pressure in patients with open-angle glaucoma or ocular hypertension. |
| Mechanism of Action | Alpha-2 adrenergic receptor agonist; reduces aqueous humor production and increases uveoscleral outflow. |
| Dosage Forms | Ophthalmic solution (eye drops) |
| Available Strengths | 0.1%, 0.15%, 0.2% |
| Dosage Frequency | Typically one drop in the affected eye(s) two to three times daily, approximately 12 hours apart, or as directed by a healthcare provider. |
| Common Side Effects | Eye redness, burning, stinging, blurred vision, dry mouth, headache, drowsiness. |
| Serious Side Effects | Allergic reactions (rash, itching, swelling, difficulty breathing), severe eye pain, vision changes, fainting, slow heart rate. |
| Drug Interactions | Beta-blockers, antihypertensives, MAO inhibitors, tricyclic antidepressants, CNS depressants. |
| Important Notes | Remove contact lenses before use and wait 15 minutes before reinserting. Use caution when driving or operating machinery, as brimonidine can cause drowsiness or blurred vision. Consult your doctor if you experience severe eye pain or vision changes. |
| Storage | Store at room temperature away from moisture and light. Keep the bottle tightly closed when not in use. |
| Missed Dose | Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Timolol, Latanoprost, Dorzolamide, Acetazolamide |
Brimonidine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Timolol | Non-selective beta-adrenergic receptor blocker | Reduces aqueous humor production. |
| Latanoprost | Prostaglandin analog | Increases uveoscleral outflow of aqueous humor. |
| Dorzolamide | Carbonic anhydrase inhibitor | Reduces aqueous humor production. |
| Acetazolamide | Carbonic anhydrase inhibitor | Reduces aqueous humor production. (Oral medication) |
Brimonidine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Eye redness | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Burning or stinging in the eye | Severe eye pain |
| Blurred vision | Vision changes |
| Dry mouth | Fainting |
| Headache | Slow heart rate |
Brimonidine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Open-Angle Glaucoma | One drop of 0.1% or 0.15% solution | One drop of 0.1% or 0.15% solution two to three times daily | Administer approximately 12 hours apart. Remove contact lenses before use. |
| Ocular Hypertension | One drop of 0.1% or 0.15% solution | One drop of 0.1% or 0.15% solution two to three times daily | Administer approximately 12 hours apart. Remove contact lenses before use. |
Brimonidine Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50–$100 |
| Without Insurance (U.S.) | $150–$200 |
| From Canada | $24.95 |
