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General Medication Fact Sheet for Briviact
| Field | Information |
|---|---|
| Medication Name | Briviact |
| Generic Name | Brivaracetam |
| Boxed/Label Warning | May cause suicidal thoughts or actions. Monitor for changes in mood or behavior. |
| Purpose | Antiepileptic medication used to treat partial-onset seizures. |
| Mechanism of Action | Binds to synaptic vesicle protein 2A (SV2A) in the brain, which may reduce neuronal excitability. |
| Dosage Forms | Oral tablets, oral solution, intravenous injection |
| Available Strengths | 10 mg, 25 mg, 50 mg, 75 mg, 100 mg |
| Dosage Frequency | Typically twice daily, approximately 12 hours apart. |
| Common Side Effects | Drowsiness, dizziness, fatigue, nausea, vomiting, headache |
| Serious Side Effects | Suicidal thoughts or actions, neuropsychiatric events (e.g., irritability, anxiety, aggression), allergic reactions (e.g., rash, swelling, difficulty breathing), coordination problems |
| Drug Interactions | Other antiepileptic drugs (e.g., carbamazepine, phenytoin), alcohol, certain sedatives or tranquilizers |
| Important Notes | Do not stop taking Briviact suddenly without consulting your doctor, as this could increase the risk of seizures. May cause drowsiness or dizziness, so use caution when driving or operating machinery. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Keppra (levetiracetam), Lamictal (lamotrigine), Topamax (topiramate), Dilantin (phenytoin) |
Briviact Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Keppra (levetiracetam) | Binds to synaptic vesicle protein 2A (SV2A). | Similar mechanism of action to Briviact; often used as a first-line treatment for seizures. |
| Lamictal (lamotrigine) | Blocks voltage-sensitive sodium channels and inhibits the release of glutamate. | Also used for bipolar disorder. Titration is important to avoid rash. |
| Topamax (topiramate) | Blocks sodium channels, enhances GABA activity, and inhibits glutamate activity. | May cause cognitive side effects and weight loss. |
| Dilantin (phenytoin) | Blocks voltage-gated sodium channels. | Older antiepileptic with a narrow therapeutic index; requires monitoring. |
Briviact Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Suicidal thoughts or actions |
| Dizziness | Neuropsychiatric events (irritability, anxiety, aggression) |
| Fatigue | Allergic reactions (rash, swelling, difficulty breathing) |
| Nausea | Coordination problems |
| Headache | Vision changes |
Briviact Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Partial-Onset Seizures (Adults) | 50 mg twice daily | 25-100 mg twice daily (based on response and tolerability) | May be taken with or without food. |
| Partial-Onset Seizures (Children 4 years and older) | Based on weight; consult physician | Based on weight and response; consult physician | Dosage must be individualized by the prescribing physician. |
Briviact Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 – $80 (depending on plan) |
| Without Insurance (U.S.) | $1,150 – $1300 |
