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General Medication Fact Sheet for Clomipramine
| Field | Information |
|---|---|
| Generic Name | Clomipramine |
| Brand Name Versions | Anafranil |
| Boxed/Label Warning | Antidepressants may increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults. |
| Purpose | Treatment of obsessive-compulsive disorder (OCD) and certain depressive disorders. |
| Mechanism of Action | Primarily inhibits the reuptake of serotonin and norepinephrine in the brain. |
| Dosage Forms | Oral capsules and tablets |
| Available Strengths | 25 mg, 50 mg, 75 mg |
| Dosage Frequency | Usually taken 1-3 times daily, or as directed by a healthcare provider. |
| Common Side Effects | Dry mouth, constipation, blurred vision, drowsiness, dizziness, sexual dysfunction. |
| Serious Side Effects | Seizures, irregular heartbeat, suicidal thoughts, serotonin syndrome. |
| Drug Interactions | MAO inhibitors, SSRIs, SNRIs, other antidepressants, certain antihistamines, and antipsychotics. |
| Important Notes | Avoid alcohol while taking this medication. May cause drowsiness. Consult a doctor if you have a history of seizures, heart problems, or glaucoma. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it’s almost time for the next dose. Do not double the dose. |
| Alternatives | Sertraline, Fluoxetine, Paroxetine, Fluvoxamine. |
Clomipramine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sertraline (Zoloft) | Selective serotonin reuptake inhibitor (SSRI) | Commonly used for OCD and depression; may have fewer side effects than clomipramine for some individuals. |
| Fluoxetine (Prozac) | Selective serotonin reuptake inhibitor (SSRI) | Another SSRI option for OCD and depression. |
| Paroxetine (Paxil) | Selective serotonin reuptake inhibitor (SSRI) | Another SSRI option for OCD and depression. |
| Fluvoxamine (Luvox) | Selective serotonin reuptake inhibitor (SSRI) | Specifically approved for the treatment of OCD. |
Clomipramine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dry mouth | Seizures |
| Constipation | Irregular heartbeat |
| Blurred vision | Suicidal thoughts or behavior |
| Drowsiness | Serotonin syndrome (symptoms include agitation, hallucinations, rapid heartbeat, and fever) |
| Dizziness | Neuroleptic Malignant Syndrome (NMS) |
| Sexual dysfunction | Angle-closure glaucoma |
Clomipramine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Obsessive-Compulsive Disorder (OCD) | 25 mg daily | 100-250 mg daily, divided doses | Dose should be gradually increased as tolerated. |
| Depression | 25 mg daily | 75-150 mg daily, divided doses | Dose should be gradually increased as tolerated. |
Clomipramine Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30 |
| Without Insurance (U.S.) | $40 – $100 |
| From Canada | $27.95 |
