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General Medication Fact Sheet for Colcrys
| Field | Information |
|---|---|
| Medication Name | Colcrys |
| Generic Name | Colchicine |
| Boxed/Label Warning | Colchicine can cause serious side effects or death if taken with certain other medicines. |
| Purpose | Treats and prevents gout flares; treats Familial Mediterranean Fever (FMF). |
| Mechanism of Action | Disrupts cytoskeletal functions by inhibiting beta-tubulin polymerization into microtubules, thereby reducing neutrophil activation and migration to inflamed areas. |
| Dosage Forms | Oral tablets |
| Available Strengths | 0.6 mg |
| Dosage Frequency | For acute gout flares: Typically 1.2 mg at the first sign of a flare, followed by 0.6 mg one hour later. For prophylaxis: 0.6 mg once or twice daily. For FMF: as directed by your doctor. |
| Common Side Effects | Nausea, vomiting, diarrhea, abdominal pain. |
| Serious Side Effects | Muscle weakness, numbness or tingling in fingers or toes, easy bruising or bleeding, signs of infection (fever, chills, sore throat), severe diarrhea or vomiting. |
| Drug Interactions | Certain antibiotics (e.g., clarithromycin, erythromycin), antifungals (e.g., ketoconazole, itraconazole), cyclosporine, HIV protease inhibitors, statins. |
| Important Notes | Colchicine can interact with many medications, so inform your doctor of all medications you are taking. Use caution in patients with renal or hepatic impairment. Avoid grapefruit juice. |
| Storage | Store at room temperature away from moisture and light. Keep out of reach of children. |
| Missed Dose | If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. |
| Alternatives | Allopurinol, Febuxostat, Probenecid, NSAIDs (e.g., Naproxen, Indomethacin), Prednisone. |
Colcrys Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Allopurinol | Xanthine oxidase inhibitor (reduces uric acid production) | Used for long-term management to prevent gout attacks. |
| Febuxostat (Uloric) | Xanthine oxidase inhibitor (reduces uric acid production) | Alternative to Allopurinol, also used for long-term management. |
| Probenecid | Uricosuric agent (increases uric acid excretion) | Helps the kidneys remove uric acid from the body. |
| Naproxen (Aleve) | Non-selective COX inhibitor | NSAID used for pain and inflammation during acute gout attacks. |
Colcrys Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Muscle weakness |
| Vomiting | Numbness or tingling in fingers or toes |
| Diarrhea | Easy bruising or bleeding |
| Abdominal pain | Signs of infection (fever, chills, sore throat) |
| Headache | Severe diarrhea or vomiting |
| Loss of appetite | Kidney problems |
Colcrys Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Acute Gout Flare | 1.2 mg (two 0.6 mg tablets) | 0.6 mg one hour later | Take at the first sign of a flare. Do not exceed 1.8 mg within a 1-hour period or 2.4 mg within a 24-hour period. |
| Gout Prophylaxis | 0.6 mg | 0.6 mg once or twice daily | Adjusted based on kidney function. |
| Familial Mediterranean Fever (FMF) | Varies by age and severity | Varies by age and severity | Follow doctor’s instructions carefully. |
Colcrys Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 – $100 |
| Without Insurance (U.S.) | $200 – $250 |
| From Canada | NA |
