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Combigan (Brimonidine Tartrate, Timolol)
| Brimonidine Tartrate / Timolol Maleate (Generic) Brimonidine Tartrate, Timolol Maleate | ||||||
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Shipped from Mauritius | ||||||
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General Medication Fact Sheet for Combigan
| Field | Information |
|---|---|
| Medication Name | Combigan |
| Generic Name | Brimonidine Tartrate and Timolol Maleate |
| Boxed/Label Warning | Contains Timolol, a beta-adrenergic blocking agent; may cause cardiac or respiratory reactions. |
| Purpose | To lower intraocular pressure (IOP) in patients with glaucoma or ocular hypertension. |
| Mechanism of Action | Brimonidine reduces aqueous humor production and increases uveoscleral outflow; Timolol reduces aqueous humor production. |
| Dosage Forms | Ophthalmic solution (eye drops) |
| Available Strengths | 0.2% Brimonidine/0.5% Timolol |
| Dosage Frequency | One drop in the affected eye(s) twice daily, approximately 12 hours apart. |
| Common Side Effects | Eye redness, burning or stinging, blurred vision, dry mouth, headache. |
| Serious Side Effects | Bradycardia, hypotension, bronchospasm, heart failure, allergic reactions. |
| Drug Interactions | Beta-blockers (oral), calcium channel blockers, antiarrhythmics, digitalis glycosides, MAO inhibitors, tricyclic antidepressants. |
| Important Notes | Remove contact lenses before use and wait 15 minutes before reinserting. Use caution in patients with cardiovascular, respiratory, or renal disease. |
| Storage | Store at room temperature, away from light and moisture. Keep the bottle tightly closed when not in use. |
| Missed Dose | If you miss a dose, instill it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Timolol, Brimonidine, Latanoprost, Travoprost, Dorzolamide. |
Combigan Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Timolol | Beta-adrenergic receptor blocker; reduces aqueous humor production. | Available as a single-agent eye drop. |
| Brimonidine (Alphagan P) | Alpha-2 adrenergic agonist; reduces aqueous humor production and increases uveoscleral outflow. | Available as a single-agent eye drop. |
| Latanoprost (Xalatan) | Prostaglandin analog; increases uveoscleral outflow. | Administered once daily in the evening. |
| Travoprost (Travatan Z) | Prostaglandin analog; increases uveoscleral outflow. | Administered once daily in the evening. |
| Dorzolamide (Trusopt) | Carbonic anhydrase inhibitor; reduces aqueous humor production. | Available as a single-agent or in combination with Timolol. |
Combigan Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Eye redness | Bradycardia (slow heart rate) |
| Burning or stinging | Hypotension (low blood pressure) |
| Blurred vision | Bronchospasm (wheezing, difficulty breathing) |
| Dry mouth | Heart failure |
| Headache | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Dizziness | Depression |
Combigan Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Glaucoma | One drop | One drop in the affected eye(s) twice daily | Administer approximately 12 hours apart. Avoid touching the dropper to the eye or any other surface. |
| Ocular Hypertension | One drop | One drop in the affected eye(s) twice daily | Administer approximately 12 hours apart. Remove contact lenses before use and wait 15 minutes before reinserting. |
Combigan Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $60 |
| Without Insurance (U.S.) | $180 – $250 |
| From Canada | $37.95 |
