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General Medication Fact Sheet for Constella
| Field | Information |
|---|---|
| Medication Name | Constella |
| Generic Name | Linaclotide |
| Purpose | Treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) |
| Mechanism of Action | Guanylate cyclase-C (GC-C) agonist that increases intestinal fluid secretion and accelerates gastrointestinal transit |
| Dosage Forms | Oral capsules |
| Available Strengths | 72 mcg, 145 mcg, 290 mcg |
| Dosage Frequency | Once daily |
| Common Side Effects | Diarrhea, abdominal pain, flatulence, abdominal distension |
| Serious Side Effects | Severe diarrhea leading to dehydration, hypovolemia, or symptomatic hypotension |
| Drug Interactions | Caution with concurrent use of medications that can cause diarrhea (e.g., laxatives, antibiotics) |
| Important Notes | Take on an empty stomach at least 30 minutes before breakfast; avoid if you have a known or suspected mechanical gastrointestinal obstruction |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Skip the missed dose and take the next dose at the regular time. Do not double the dose. |
| Alternatives | Amitiza, Lubiprostone, Trulance, Plecanatide |
Constella Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Amitiza (Lubiprostone) | Chloride channel activator that increases fluid secretion in the intestine | Used for IBS-C and chronic idiopathic constipation. |
| Trulance (Plecanatide) | Guanylate cyclase-C (GC-C) agonist, similar to Constella | Another option for IBS-C and chronic idiopathic constipation. |
| Lactulose | Osmotic laxative | Works by drawing water into the colon, which can help soften the stool and make it easier to pass. |
| Polyethylene Glycol (Miralax) | Osmotic laxative | Works by drawing water into the colon, which can help soften the stool and make it easier to pass. |
Constella Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Severe diarrhea leading to dehydration |
| Abdominal pain | Hypovolemia (low blood volume) |
| Flatulence | Symptomatic hypotension (low blood pressure) |
Constella Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| IBS-C | 72 mcg | 72 mcg once daily | Take on an empty stomach at least 30 minutes before breakfast. |
| CIC | 145 mcg | 145 mcg once daily; may increase to 290 mcg if needed | Take on an empty stomach at least 30 minutes before breakfast. |
Constella Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 |
| Without Insurance (U.S.) | $700 – $800 |
| From Canada | $145.50 |
