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General Medication Fact Sheet for Cosentyx
| Field | Information |
|---|---|
| Medication Name | Cosentyx |
| Generic Name | Secukinumab |
| Boxed/Label Warning | Increased risk of serious infections. |
| Purpose | Treatment of psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. |
| Mechanism of Action | Selective interleukin-17A (IL-17A) antagonist; binds to IL-17A and inhibits its interaction with the IL-17 receptor. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 150 mg/mL, 75 mg/0.5 mL |
| Dosage Frequency | Varies based on condition; typically weekly for 5 weeks, then monthly. |
| Common Side Effects | Upper respiratory infections, cold sores, diarrhea |
| Serious Side Effects | Serious infections (e.g., tuberculosis), Crohn’s disease, ulcerative colitis, allergic reactions. |
| Drug Interactions | Live vaccines, TNF inhibitors, IL-12/23 inhibitors. |
| Important Notes | Screen for tuberculosis before starting; avoid live vaccines. |
| Storage | Store in the refrigerator at 2-8°C (36-46°F). Do not freeze. Protect from light. |
| Missed Dose | Inject the missed dose as soon as you remember, then continue with your regular schedule. |
| Alternatives | Humira (adalimumab), Enbrel (etanercept), Stelara (ustekinumab), Taltz (ixekizumab) |
Cosentyx Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Humira (adalimumab) | TNF-alpha inhibitor | Used for psoriasis, psoriatic arthritis, and ankylosing spondylitis. |
| Enbrel (etanercept) | TNF-alpha inhibitor | Used for psoriasis, psoriatic arthritis, and ankylosing spondylitis. |
| Stelara (ustekinumab) | IL-12/23 inhibitor | Used for psoriasis and psoriatic arthritis. |
| Taltz (ixekizumab) | IL-17A inhibitor | Similar mechanism of action to Cosentyx. |
Cosentyx Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Upper respiratory infections | Serious infections (e.g., tuberculosis) |
| Cold sores | Crohn’s disease |
| Diarrhea | Ulcerative colitis |
| Injection site reactions (redness, pain, swelling) | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Runny nose | New or worsening inflammatory bowel disease |
Cosentyx Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Psoriasis | 300 mg (two 150 mg injections) at Weeks 0, 1, 2, 3, and 4 | 300 mg every month | Administered as subcutaneous injection. |
| Psoriatic Arthritis | 150 mg at Weeks 0, 1, 2, 3, and 4 | 150 mg every month | May increase to 300 mg monthly for patients with concomitant moderate-to-severe plaque psoriasis. |
| Ankylosing Spondylitis | 150 mg at Weeks 0, 1, 2, 3, and 4 | 150 mg every month | Administered as subcutaneous injection. |
| Non-radiographic axial spondyloarthritis | 150 mg at Weeks 0, 1, 2, 3, and 4 | 150 mg every month | Administered as subcutaneous injection. |
Cosentyx Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $1,000 – $2,500 |
| Without Insurance (U.S.) | $6,500 – $7,200 |
| From CPS | $1,299.95 |
