Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Description
General Medication Fact Sheet for Cotellic
| Field | Information |
|---|---|
| Medication Name | Cotellic |
| Generic Name | Cobimetinib |
| Boxed/Label Warning | May cause new primary malignancies, serious skin toxicities, hemorrhage, cardiomyopathy, retinal pigment epithelial detachments, and embryo-fetal toxicity. |
| Purpose | Used in combination with vemurafenib to treat melanoma that has spread to other parts of the body or cannot be removed by surgery, and has a certain type of abnormal BRAF gene. |
| Mechanism of Action | A kinase inhibitor that targets MEK (MAPK/ERK kinase), a protein kinase involved in cell growth. It helps slow down or stop the growth of cancer cells. |
| Dosage Forms | Oral tablets |
| Available Strengths | 20 mg |
| Dosage Frequency | Typically once daily for 21 days followed by a 7-day rest period, as part of a 28-day cycle. |
| Common Side Effects | Diarrhea, nausea, vomiting, fatigue, rash, photosensitivity, liver enzyme elevations, muscle pain, swelling. |
| Serious Side Effects | New primary malignancies, serious skin toxicities (Stevens-Johnson syndrome, toxic epidermal necrolysis), hemorrhage, cardiomyopathy (decreased heart function), retinal pigment epithelial detachments, embryo-fetal toxicity, venous thromboembolism. |
| Drug Interactions | Strong CYP3A inhibitors (e.g., ketoconazole), strong CYP3A inducers (e.g., rifampin), drugs that prolong the QT interval. |
| Important Notes | Must be used in combination with vemurafenib. Use effective contraception during treatment and for at least 2 weeks after the last dose. Report any new skin lesions or changes in vision to your doctor immediately. Avoid prolonged sun exposure. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | If a dose is missed by more than 12 hours, skip the dose and take the next dose at the regular time. Do not double the dose. |
| Alternatives | Zelboraf (vemurafenib) – often used in combination with Cotellic, Tafinlar (dabrafenib), Mekinist (trametinib). Selumetinib, Binimetinib. |
Cotellic Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Zelboraf (vemurafenib) | BRAF kinase inhibitor | Used in combination with Cotellic for BRAF V600 mutation-positive melanoma. |
| Tafinlar (dabrafenib) | BRAF kinase inhibitor | Alternative BRAF inhibitor, often used in combination with a MEK inhibitor. |
| Mekinist (trametinib) | MEK inhibitor | A MEK inhibitor that can be used in combination with a BRAF inhibitor in certain melanoma cases. |
| Selumetinib | MEK inhibitor | Used to treat neurofibromatosis type 1 (NF1) in pediatric patients. |
| Binimetinib | MEK inhibitor | Can be used in combination with encorafenib. |
Cotellic Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | New primary malignancies |
| Nausea | Serious skin toxicities (Stevens-Johnson syndrome, toxic epidermal necrolysis) |
| Vomiting | Hemorrhage |
| Fatigue | Cardiomyopathy (decreased heart function) |
| Rash | Retinal pigment epithelial detachments (vision problems) |
| Photosensitivity | Embryo-fetal toxicity |
| Muscle pain | Venous thromboembolism (blood clots) |
| Swelling (edema) | Liver enzyme elevations |
Cotellic Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Metastatic Melanoma (with BRAF V600 mutation) | 60 mg (three 20 mg tablets) | 60 mg once daily for 21 days, followed by a 7-day rest period (28-day cycle) | Administer in combination with vemurafenib. Take at the same time each day. Do not crush or chew tablets. |
Cotellic Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $2,500 – $10,000 |
| Without Insurance (U.S.) | $20,000 |
| From CPS | $9,454.99 |
Why Americans Buy Cotellic from Canada Pharmacy Store?
Why Americans Buy Cotellic from Canada Pharmacy Store?
Americans have trouble affording Cotellic due to numerous factors—but at Canada Pharmacy Store, we offer a safe, affordable alternative. That’s why thousands of Americans trust us to fill their prescriptions with real savings and real service.
Big Savings on U.S. Medications
Our customers save up to 80% on their Cotellic prescriptions compared to U.S. pharmacy prices by ordering through licensed Canadian and international pharmacies.
Free Prescription Transfers
We make it easy! Our pharmacy team can transfer your Cotellic prescriptions directly from your doctor or local pharmacy – completely free of charge.
Direct Access to Experts
Our licensed pharmacists are available to support you, answer your questions, and help ensure you’re confident in your treatment.
Referral Discounts
Spread the word—when you refer friends or family, you both save. It’s our way of saying thanks.
Discreet U.S. Shipping
All orders are packaged discreetly and shipped securely to your U.S. address, with your privacy and safety as top priorities.
Trusted by Americans Nationwide
With years of experience and verified medication sources, we’ve become a go-to solution for Americans looking to cut costs without compromising care.
How to Order Cotellic Online
How to Order Cotellic Online
Step 1
Select Your Prescribed Cotellic Dosage
Choose the strength and quantity as directed by your healthcare provider and add it to your cart.
Step 2
Proceed Through Secure Checkout
Follow the steps to complete your order and provide necessary shipping and payment details.
Step 3
Upload Your Cotellic Prescription
Submit a prescription from a licensed U.S. healthcare provider that matches your order.
At Canada Pharmacy Store, patient safety comes first. We strictly comply with prescription regulations and do not ship any medication without a valid, verifiable prescription. Orders may be declined if a prescription appears falsified or altered in any way. We take these precautions to protect your health and ensure lawful, responsible practices.
Guarantee
Our Guarantee When You Buy Cotellic Through Canada Pharmacy Store
At Canada Pharmacy Store, your safety and satisfaction are our top priorities. We supply only authentic, high-quality medications by working exclusively with licensed Canadian pharmacies and trusted international partners. Every order is filled in accordance with strict regulatory standards and includes medication that’s fully approved by Health Canada or other recognized health authorities such as the MHRA (UK), HSA (Singapore), and the Pharmacy Board of Mauritius.
The Cotellic you receive is the same active medication as what’s available in the U.S.—the only difference is the packaging, which reflects its country of origin. Our licensed healthcare professionals review each order carefully to ensure it matches your prescription exactly.
To get Cotellic at a lower price, simply place your order above or give us a call at 1-888-903-2240
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