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General Medication Fact Sheet for Dabigatran
| Field | Information |
|---|---|
| Generic Name | Dabigatran |
| Brand Name Versions | Pradaxa |
| Boxed/Label Warning | Dabigatran can cause significant bleeding. Risk is increased in patients taking other anticoagulants, antiplatelet agents, and NSAIDs. Discontinue dabigatran prior to elective surgery. |
| Purpose | Anticoagulant used to prevent and treat blood clots. |
| Mechanism of Action | Direct thrombin inhibitor, preventing clot formation. |
| Dosage Forms | Oral capsules |
| Available Strengths | 75 mg, 110 mg, 150 mg |
| Dosage Frequency | Typically twice daily, as directed by a healthcare provider. |
| Common Side Effects | Indigestion, stomach pain, nausea, diarrhea, bleeding more easily. |
| Serious Side Effects | Severe bleeding, allergic reactions (rash, itching, swelling, difficulty breathing). |
| Drug Interactions | Other anticoagulants (e.g., Warfarin, heparin), antiplatelet drugs (e.g., aspirin, clopidogrel), NSAIDs, certain antifungals (e.g., ketoconazole), certain antivirals (e.g., ritonavir). |
| Important Notes | Do not open, break, or chew capsules. Swallow whole with a full glass of water. Contact your doctor immediately if you experience signs of bleeding. |
| Storage | Store at room temperature away from moisture and light in its original container. |
| Missed Dose | Take as soon as you remember unless it is close to your next scheduled dose. Do not double the dose. |
| Alternatives | Warfarin, Rivaroxaban, Apixaban, Edoxaban |
Dabigatran Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Warfarin (Coumadin, Jantoven) | Vitamin K antagonist, affecting clotting factor synthesis. | Requires regular blood monitoring. |
| Rivaroxaban (Xarelto) | Factor Xa inhibitor. | Once-daily oral medication. |
| Apixaban (Eliquis) | Factor Xa inhibitor. | Twice-daily oral medication. |
| Edoxaban (Savaysa) | Factor Xa inhibitor. | Once-daily oral medication. |
Dabigatran Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Indigestion | Severe bleeding (e.g., nosebleeds, heavy menstrual bleeding, blood in urine or stool) |
| Stomach pain | Stroke |
| Nausea | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Diarrhea | Bleeding in the brain |
| Bleeding more easily | Anemia (low red blood cell count) |
Dabigatran Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Nonvalvular Atrial Fibrillation (Stroke Prevention) | 150 mg | 150 mg twice daily | Adjusted based on kidney function; take with a full glass of water. |
| Treatment of DVT/PE | 150 mg | 150 mg twice daily | Usually started after 5-10 days of parenteral anticoagulation. |
| Prevention of DVT/PE After Hip Replacement Surgery | 110 mg | 220 mg once daily | Start within 1-4 hours after surgery and after hemostasis has been established. |
Dabigatran Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 |
| Without Insurance (U.S.) | $420 – $1,550 |
| From CPS | $59.95 |
