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General Medication Fact Sheet for Daxas
| Field | Information |
|---|---|
| Medication Name | Daxas |
| Generic Name | Roflumilast |
| Boxed/Label Warning | None |
| Purpose | To reduce the risk of COPD exacerbations. |
| Mechanism of Action | Phosphodiesterase-4 (PDE4) inhibitor, reducing inflammation in the lungs. |
| Dosage Forms | Oral tablets |
| Available Strengths | 500 mcg |
| Dosage Frequency | Once daily |
| Common Side Effects | Diarrhea, weight loss, nausea, headache, insomnia. |
| Serious Side Effects | Mental health changes (depression, suicidal thoughts), unexplained weight loss, severe allergic reactions. |
| Drug Interactions | Strong CYP3A4 inducers (e.g., rifampin, phenytoin, phenobarbital, carbamazepine). |
| Important Notes | Monitor for changes in mood or weight. Not a bronchodilator and should not be used as a rescue medication for sudden breathing problems. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Theophylline, Budesonide/Formoterol (Symbicort), Fluticasone/Salmeterol (Advair), Tiotropium (Spiriva). |
Daxas Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Theophylline | Bronchodilator, phosphodiesterase inhibitor | Requires monitoring of blood levels due to narrow therapeutic window. |
| Budesonide/Formoterol (Symbicort) | Inhaled corticosteroid/long-acting beta-agonist | Combination inhaler used for COPD maintenance therapy. |
| Fluticasone/Salmeterol (Advair) | Inhaled corticosteroid/long-acting beta-agonist | Another combination inhaler for COPD maintenance. |
| Tiotropium (Spiriva) | Long-acting muscarinic antagonist (LAMA) | Bronchodilator that relaxes airway muscles. |
Daxas Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Mental health changes (depression, suicidal thoughts) |
| Weight loss | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Nausea | Unexplained weight loss |
| Headache | Pneumonia |
| Insomnia | Liver problems |
Daxas Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| COPD (to reduce exacerbations) | 250 mcg once daily for 7 days | 500 mcg once daily | Swallow the tablet whole with water. Not for acute bronchospasm. |
Daxas Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 – $100 |
| Without Insurance (U.S.) | $700 – $2,500 |
| From CPS | $89.95 |
