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General Medication Fact Sheet for Deferasirox
| Field | Information |
|---|---|
| Generic Name | Deferasirox |
| Brand Name Versions | Exjade, Jadenu |
| Boxed/Label Warning | Risk of kidney and liver problems, and gastrointestinal bleeding. |
| Purpose | Iron chelator used to reduce iron overload in patients receiving chronic blood transfusions. |
| Mechanism of Action | Binds to iron and forms a complex that is excreted from the body, reducing excess iron levels. |
| Dosage Forms | Oral tablets, oral granules |
| Available Strengths | 125 mg, 180 mg, 360 mg, 500 mg, 90 mg (Jadenu Sprinkle) |
| Dosage Frequency | Once daily |
| Common Side Effects | Nausea, vomiting, diarrhea, abdominal pain, skin rash |
| Serious Side Effects | Kidney problems, liver problems, gastrointestinal bleeding, hearing loss, vision changes |
| Drug Interactions | Aluminum-containing antacids, repaglinide, theophylline, CYP3A4 inducers (e.g., rifampin), CYP3A4 inhibitors (e.g., ketoconazole) |
| Important Notes | Take on an empty stomach at least 30 minutes before food. Regular monitoring of kidney and liver function is required. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it is close to your next dose. Do not double the dose. |
| Alternatives | Deferoxamine, Deferiprone |
Deferasirox Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Deferoxamine (Desferal) | Binds to iron in the blood and tissues, allowing it to be excreted by the kidneys. | Administered via subcutaneous or intravenous infusion. |
| Deferiprone (Ferriprox) | Binds to iron in the blood and tissues, forming a complex that is excreted in the urine. | Available as an oral solution or tablet. |
Deferasirox Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Kidney problems (increased creatinine, renal tubular disorders) |
| Vomiting | Liver problems (increased liver enzymes, liver failure) |
| Diarrhea | Gastrointestinal bleeding (stomach ulcers, black stools) |
| Abdominal pain | Hearing loss (auditory or vestibular abnormalities) |
| Skin rash | Vision changes (cataracts, retinopathy) |
Deferasirox Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Transfusional Iron Overload (Exjade) | 20 mg/kg daily | Adjust based on serum ferritin levels. Usual range: 20-40 mg/kg daily. | Take on an empty stomach at least 30 minutes before food. Disperse tablets in water or juice. |
| Transfusional Iron Overload (Jadenu) | 14 mg/kg daily | Adjust based on serum ferritin levels. Usual range: 14-28 mg/kg daily. | Take on an empty stomach at least 30 minutes before food. Swallow whole; do not chew, crush, or split tablets. |
Deferasirox Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 |
| Without Insurance (U.S.) | $3,000 – $6,500 |
| From CPS | $284.95 |
