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General Medication Fact Sheet for Diacomit
| Field | Information |
|---|---|
| Medication Name | Diacomit |
| Generic Name | Stiripentol |
| Purpose | Antiepileptic drug used in conjunction with clobazam and valproate for the treatment of Dravet syndrome |
| Mechanism of Action | The exact mechanism is not fully understood, but it is believed to enhance GABAergic neurotransmission |
| Dosage Forms | Oral capsules, oral powder for suspension |
| Available Strengths | 250 mg capsules, 500 mg capsules, 250 mg powder sachets, 500 mg powder sachets |
| Dosage Frequency | Typically divided into 2 or 3 doses per day, as directed by a healthcare provider |
| Common Side Effects | Drowsiness, ataxia (loss of coordination), decreased appetite, weight loss, hypotonia (low muscle tone) |
| Serious Side Effects | Neutropenia (low white blood cell count), thrombocytopenia (low platelet count), elevated liver enzymes, status epilepticus |
| Drug Interactions | Clobazam, valproate, CYP450 enzyme inhibitors (e.g., ketoconazole), CYP450 enzyme inducers (e.g., rifampin), other antiepileptic drugs |
| Important Notes | Must be used in combination with clobazam and valproate; monitor blood counts and liver function regularly; may cause drowsiness or dizziness |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember, unless it is almost time for your next dose. Do not double the dose. Consult your healthcare provider. |
| Alternatives | Clobazam (Onfi), Valproic Acid (Depakote), Fenfluramine (Fintepla), Cannabidiol (Epidiolex) |
Diacomit Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Clobazam (Onfi) | Benzodiazepine; enhances GABA-A receptor activity | Used as an add-on treatment for seizures. |
| Valproic Acid (Depakote) | Increases GABA levels in the brain | Broad-spectrum antiepileptic drug. |
| Fenfluramine (Fintepla) | Serotonin releasing agent and sigma-1 receptor agonist. | Used for seizures associated with Dravet syndrome in patients ≥ 2 years. |
| Cannabidiol (Epidiolex) | The exact mechanism of action is not fully understood, but is thought to reduce neuronal excitability. | Plant-derived cannabinoid for treating seizures associated with Dravet syndrome and Lennox-Gastaut syndrome. |
Diacomit Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Drowsiness | Neutropenia (low white blood cell count) |
| Ataxia (loss of coordination) | Thrombocytopenia (low platelet count) |
| Decreased appetite | Elevated liver enzymes |
| Weight loss | Status epilepticus |
| Hypotonia (low muscle tone) | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
Diacomit Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Dravet Syndrome | 50 mg/kg/day, divided into 2 or 3 doses | Individualized based on response and tolerability, up to a maximum of 100 mg/kg/day | Administer with food. Must be used with clobazam and valproate. |
Diacomit Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 |
| Without Insurance (U.S.) | $150 – $250 |
| From CPS | $371.60 |
