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General Medication Fact Sheet for Diclofenac
| Field | Information |
|---|---|
| Generic Name | Diclofenac |
| Brand Name Versions | Voltaren, Cataflam, Zipsor |
| Boxed/Label Warning | NSAIDs may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. NSAIDs also increase the risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. |
| Purpose | Non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation. |
| Mechanism of Action | Inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis. |
| Dosage Forms | Oral tablets, topical gel, topical solution, injection. |
| Available Strengths | 25 mg, 50 mg, 75 mg, 100 mg (oral); 1% (topical gel/solution). |
| Dosage Frequency | Typically two to three times daily for oral forms; topical forms as directed. |
| Common Side Effects | Upset stomach, heartburn, nausea, headache, dizziness. |
| Serious Side Effects | Gastrointestinal bleeding, liver problems, kidney problems, heart attack, stroke, allergic reactions. |
| Drug Interactions | Other NSAIDs, anticoagulants (e.g., warfarin), aspirin, certain antidepressants (SSRIs), ACE inhibitors, diuretics. |
| Important Notes | Take with food to minimize stomach upset; consult a doctor if you have heart, liver, or kidney problems. Long-term use may increase the risk of cardiovascular events. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Ibuprofen, Naproxen, Celecoxib, Meloxicam. |
Diclofenac Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Ibuprofen (Advil, Motrin) | Non-selective COX inhibitor | Commonly used for mild to moderate pain relief. |
| Naproxen (Aleve) | Non-selective COX inhibitor | Longer-lasting pain relief compared to ibuprofen. |
| Celecoxib (Celebrex) | Selective COX-2 inhibitor | May have a lower risk of gastrointestinal side effects compared to non-selective NSAIDs. |
| Meloxicam (Mobic) | Selective COX-2 inhibitor | Prescription NSAID often used for arthritis. |
Diclofenac Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Upset stomach | Gastrointestinal bleeding |
| Heartburn | Liver problems |
| Nausea | Kidney problems |
| Headache | Heart attack |
| Dizziness | Stroke |
| Constipation | Allergic reactions (rash, itching, swelling, difficulty breathing) |
Diclofenac Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Osteoarthritis | 50 mg | 50 mg two to three times daily | Take with food. |
| Rheumatoid Arthritis | 50 mg | 50 mg three to four times daily | Take with food. |
| Ankylosing Spondylitis | 25 mg | 25 mg four times daily | Take with food. |
| Pain Relief | 50 mg | 50 mg two to three times daily as needed | Take with food. Do not exceed recommended daily dose. |
Diclofenac Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $15 |
| Without Insurance (U.S.) | $20 – $35 |
| From CPS | $23.95 |


