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General Medication Fact Sheet for Dificid
| Field | Information |
|---|---|
| Medication Name | Dificid |
| Generic Name | Fidaxomicin |
| Purpose | Treatment of Clostridium difficile-associated diarrhea (CDAD), also known as Clostridium difficile infection (CDI) |
| Mechanism of Action | Inhibits RNA polymerase, an enzyme essential for bacterial RNA synthesis |
| Dosage Forms | Oral tablets, Oral suspension |
| Available Strengths | 200 mg |
| Dosage Frequency | Twice daily for 10 days, or as directed by a healthcare provider |
| Common Side Effects | Nausea, vomiting, abdominal pain, gastrointestinal bleeding, diarrhea |
| Serious Side Effects | Severe allergic reactions (rash, itching, swelling, difficulty breathing), worsening of C. difficile infection symptoms. |
| Drug Interactions | P-glycoprotein (P-gp) inhibitors (e.g., ketoconazole, erythromycin) may increase fidaxomicin levels. |
| Important Notes | Complete the full course of treatment, even if you feel better. Report any severe or persistent side effects to your doctor. |
| Storage | Store at room temperature away from moisture and light. Keep out of reach of children. |
| Missed Dose | Take as soon as you remember; if it is close to the time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose. |
| Alternatives | Vancomycin, Metronidazole, Bezlotoxumab |
Dificid Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Vancomycin | Inhibits cell wall synthesis in bacteria. | A commonly used antibiotic for C. difficile infection, available in oral form. |
| Metronidazole | Inhibits nucleic acid synthesis in bacteria. | An older antibiotic also used for C. difficile infection, typically used for milder cases. |
| Bezlotoxumab (Zinplava) | Neutralizes C. difficile toxin B. | A monoclonal antibody used to reduce the recurrence of C. difficile infection when used with antibiotics. |
Dificid Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Vomiting | Worsening of C. difficile infection symptoms |
| Abdominal pain | Significant gastrointestinal bleeding |
Dificid Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Clostridium difficile Infection (CDI) | 200 mg | 200 mg twice daily for 10 days | May be taken with or without food. |
Dificid Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 |
| Without Insurance (U.S.) | $4,700 – $5,500 |
| From CPS | $2,298.95 |
