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General Medication Fact Sheet for Digoxin
| Field | Information |
|---|---|
| Generic Name | Digoxin |
| Brand Name Versions | Lanoxin, Digox |
| Boxed/Label Warning | This drug should be administered with extreme caution to patients with renal insufficiency, hypothyroidism, or severe respiratory disease. |
| Purpose | Treats heart failure and certain types of irregular heartbeats (atrial fibrillation, atrial flutter). |
| Mechanism of Action | Inhibits the sodium-potassium ATPase pump in heart muscle cells, increasing intracellular calcium and improving heart contractility; also slows down electrical conduction through the AV node. |
| Dosage Forms | Oral tablets, oral solution, injection |
| Available Strengths | Tablets: 0.125 mg, 0.25 mg; Oral Solution: 0.05 mg/mL; Injection: 0.25 mg/mL |
| Dosage Frequency | Typically once daily, or as directed by a healthcare provider. |
| Common Side Effects | Nausea, vomiting, diarrhea, loss of appetite, dizziness, headache. |
| Serious Side Effects | Irregular heartbeat (arrhythmia), slow heart rate (bradycardia), vision changes (blurred vision, halos), confusion, severe weakness. |
| Drug Interactions | Amiodarone, quinidine, verapamil, diltiazem, potassium-depleting diuretics (e.g., Furosemide, hydrochlorothiazide), certain antibiotics (e.g., erythromycin, clarithromycin), antacids, St. John’s Wort. |
| Important Notes | Requires regular monitoring of digoxin blood levels. Diet high in fiber can interfere with absorption. Potassium levels need to be monitored and maintained. Consult your healthcare provider if you experience any symptoms of toxicity. |
| Storage | Store at room temperature away from moisture and light. Keep out of reach of children. |
| Missed Dose | Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Beta-blockers, ACE inhibitors, ARBs, diuretics, Amiodarone. |
Digoxin Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Metoprolol (Lopressor, Toprol XL) | Beta-blocker: Blocks the effects of adrenaline, slowing heart rate and lowering blood pressure. | Used for heart failure and high blood pressure. |
| Enalapril (Vasotec) | ACE Inhibitor: Blocks the production of angiotensin II, relaxing blood vessels. | Used for heart failure and high blood pressure. |
| Losartan (Cozaar) | ARB: Blocks the action of angiotensin II, relaxing blood vessels. | Used for heart failure and high blood pressure. |
| Furosemide (Lasix) | Loop Diuretic: Increases urine production, reducing fluid overload. | Used for heart failure to reduce swelling. |
| Amiodarone (Pacerone, Cordarone) | Antiarrhythmic: Affects sodium, potassium, and calcium channels in heart cells to stabilize heart rhythm. | Used for atrial fibrillation and other arrhythmias. |
Digoxin Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Irregular heartbeat (arrhythmia) |
| Vomiting | Slow heart rate (bradycardia) |
| Diarrhea | Vision changes (blurred vision, halos) |
| Loss of appetite | Confusion |
| Dizziness | Severe weakness |
| Headache | Severe stomach pain |
Digoxin Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Heart Failure | 0.125 – 0.25 mg | 0.125 – 0.25 mg daily | Dose is highly individualized based on renal function and other factors. |
| Atrial Fibrillation | 0.125 – 0.25 mg | 0.125 – 0.25 mg daily | Dose is highly individualized based on heart rate and other factors. |
Digoxin Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 |
| Without Insurance (U.S.) | $10- $20 |
| From CPS | $15.95 |
