Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
General Medication Fact Sheet for Domperidone
| Field | Information |
|---|---|
| Generic Name | Domperidone |
| Brand Name Versions | Motilium |
| Purpose | Treats nausea, vomiting, and gastroparesis; sometimes used off-label to increase breast milk production |
| Mechanism of Action | Dopamine D2 receptor antagonist; increases gastrointestinal peristalsis and prolactin release |
| Dosage Forms | Oral tablets |
| Available Strengths | 10 mg |
| Dosage Frequency | Typically three times daily, 15-30 minutes before meals, or as directed by a healthcare provider |
| Common Side Effects | Dry mouth, headache, abdominal cramps, diarrhea |
| Serious Side Effects | Cardiac arrhythmias, sudden cardiac death (rare but possible, especially at high doses or in susceptible individuals) |
| Drug Interactions | CYP3A4 inhibitors (e.g., ketoconazole, Erythromycin), QT-prolonging drugs (e.g., amiodarone), anticholinergics |
| Important Notes | Use with caution in patients with heart conditions; consult a doctor before use, especially if you have a history of cardiac problems |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Metoclopramide, Erythromycin, Ondansetron |
Domperidone Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Metoclopramide (Reglan) | Dopamine D2 receptor antagonist and 5-HT4 receptor agonist | Also increases gastrointestinal motility, but carries a risk of tardive dyskinesia with long-term use. |
| Erythromycin | Motilin receptor agonist | Stimulates gastric emptying. Primarily an antibiotic, but can be used off-label for gastroparesis. |
| Ondansetron (Zofran) | 5-HT3 receptor antagonist | Primarily used for nausea and vomiting, especially chemotherapy-induced. Does not affect gastric motility. |
Domperidone Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dry mouth | Cardiac arrhythmias |
| Headache | Sudden cardiac death (rare) |
| Abdominal cramps | QT prolongation |
| Diarrhea | Galactorrhea (milk production in men or non-breastfeeding women) |
| Dizziness | Extrapyramidal symptoms (muscle stiffness, tremors – rare) |
Domperidone Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Nausea and Vomiting | 10 mg | 10 mg three times daily | Take 15-30 minutes before meals. |
| Gastroparesis | 10 mg | 10 mg three times daily | Take 15-30 minutes before meals. |
| To Increase Breast Milk Production (Off-label) | 10 mg | 10-20 mg three to four times daily | Consult with a healthcare provider for appropriate use and duration. |
Domperidone Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | NA |
| Without Insurance (U.S.) | NA |
| From Canada | NA |
