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General Medication Fact Sheet for Duobrii
| Field | Information |
|---|---|
| Medication Name | Duobrii |
| Generic Name | Halobetasol Propionate and Tazarotene |
| Boxed/Label Warning | Tazarotene can cause birth defects. Females of reproductive potential should use effective contraception. |
| Purpose | Treatment of plaque psoriasis in adults. |
| Mechanism of Action | Halobetasol Propionate is a high-potency corticosteroid that reduces inflammation. Tazarotene is a retinoid prodrug that normalizes skin cell differentiation and reduces inflammation. |
| Dosage Forms | Topical lotion |
| Available Strengths | 0.01% / 0.045% (Halobetasol Propionate / Tazarotene) |
| Dosage Frequency | Apply a thin layer to affected areas once daily. |
| Common Side Effects | Application site reactions (itching, burning, stinging, dryness), folliculitis, skin atrophy. |
| Serious Side Effects | Adrenal suppression, Cushing’s syndrome, hyperglycemia, skin irritation, photosensitivity. |
| Drug Interactions | May interact with other topical medications, especially those containing corticosteroids or retinoids. |
| Important Notes | For topical use only. Avoid contact with eyes, mouth, and other mucous membranes. Not for use in pregnant women. Use effective contraception if of childbearing potential. Do not use occlusive dressings unless directed by a physician. |
| Storage | Store at room temperature, away from heat and direct light. Keep out of reach of children. |
| Missed Dose | Apply as soon as you remember. If it is almost time for your next dose, skip the missed dose and apply the next dose at the regular time. Do not apply a double dose to make up for the missed dose. |
| Alternatives | Calcipotriene, Betamethasone Dipropionate, Tazarotene (alone), Clobetasol Propionate |
Duobrii Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Calcipotriene | Vitamin D analog that inhibits keratinocyte proliferation and enhances keratinocyte differentiation. | Available as a cream, ointment, or solution. Often used as a first-line treatment for psoriasis. |
| Betamethasone Dipropionate | High-potency topical corticosteroid that reduces inflammation and suppresses the immune response. | Available as a cream, ointment, or lotion. Use should be limited to short periods due to potential side effects. |
| Tazarotene (Tazorac) | Topical retinoid prodrug that normalizes skin cell differentiation and reduces inflammation. | Available as a cream, gel, or foam. Can be irritating to the skin. |
| Clobetasol Propionate | Very high-potency topical corticosteroid that reduces inflammation and suppresses the immune response. | Available as a cream, ointment, lotion, solution, gel, or shampoo. Should be used for short periods due to potential side effects. |
Duobrii Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Application site itching | Adrenal suppression |
| Application site burning | Cushing’s syndrome |
| Application site stinging | Hyperglycemia |
| Application site dryness | Skin atrophy (thinning of the skin) |
| Folliculitis | Photosensitivity (increased sensitivity to sunlight) |
Duobrii Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Plaque Psoriasis | Apply a thin layer | Apply a thin layer once daily | Apply to affected areas once daily. Do not use occlusive dressings unless directed by a physician. Avoid contact with eyes, mouth, and other mucous membranes. |
Duobrii Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 – $200 |
| Without Insurance (U.S.) | $650 – $750 |
| From CPS | $303.90 |
