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General Medication Fact Sheet for Dupixent
| Field | Information |
|---|---|
| Medication Name | Dupixent |
| Generic Name | Dupilumab |
| Purpose | Treatment of atopic dermatitis (eczema), asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and eosinophilic esophagitis. |
| Mechanism of Action | Monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling, key drivers of type 2 inflammation. |
| Dosage Forms | Subcutaneous injection |
| Available Strengths | 200 mg/1.14 mL, 300 mg/2 mL pre-filled syringe or pre-filled pen |
| Dosage Frequency | Varies by condition; typically every other week or every four weeks. See Dosage Guide below. |
| Common Side Effects | Injection site reactions (redness, swelling, pain), eye problems (conjunctivitis, keratitis), cold sores, high count of eosinophils. |
| Serious Side Effects | Allergic reactions (rash, itching, hives, swelling of the face, lips, tongue, or throat, trouble breathing), new or worsening eye problems, joint pain, parasitic infection. |
| Drug Interactions | Live vaccines should be avoided. Corticosteroids should be tapered slowly if possible. |
| Important Notes | Inform your doctor of all medical conditions, including eye problems and parasitic infections, before starting Dupixent. Use caution when operating heavy machinery. |
| Storage | Store in the refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light. Do not freeze. If needed, Dupixent may be stored at room temperature up to 77°F (25°C) for a maximum of 14 days, after which it must be discarded. |
| Missed Dose | Administer the missed dose as soon as possible. Adjust the dosing schedule accordingly while maintaining the prescribed dosing interval. |
| Alternatives | Adbry (tralokinumab), Rinvoq (upadacitinib), Opzelura (ruxolitinib cream) Eucrisa (crisaborole), Corticosteroids (topical or systemic) |
Dupixent Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Adbry (tralokinumab) | IL-13 antagonist | Another biologic injectable medication for atopic dermatitis. |
| Rinvoq (upadacitinib) | JAK inhibitor | Oral medication for atopic dermatitis, also used for other inflammatory conditions. |
| Opzelura (ruxolitinib cream) | JAK inhibitor | Topical cream for mild to moderate atopic dermatitis. |
| Eucrisa (crisaborole) | Phosphodiesterase 4 (PDE4) inhibitor | Non-steroidal topical ointment for mild to moderate atopic dermatitis. |
| Corticosteroids (topical or systemic) | Anti-inflammatory | Used to reduce inflammation but can have significant side effects with long-term use. |
Dupixent Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Injection site reactions (redness, swelling, pain) | Allergic reactions (rash, itching, hives, swelling of the face, lips, tongue, or throat, trouble breathing) |
| Eye problems (conjunctivitis, keratitis) | New or worsening eye problems |
| Cold sores | Joint pain |
| High count of eosinophils | Parasitic infection |
Dupixent Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Atopic Dermatitis (Adults) | 600 mg (two 300 mg injections) | 300 mg every other week | Subcutaneous injection. Rotate injection sites. |
| Atopic Dermatitis (Children 6-11 years, ≥30 kg) | 300 mg | 300 mg every 4 weeks | Subcutaneous injection. Rotate injection sites. |
| Asthma (Adults) | 400 mg (two 200 mg injections) or 600mg (two 300mg injections) depending on concomitant oral corticosteroids | 200 mg every other week or 300mg every other week depending on concomitant oral corticosteroids | Subcutaneous injection. Rotate injection sites. |
| Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) | 600 mg (two 300 mg injections) | 300 mg every other week | Subcutaneous injection. Rotate injection sites. |
| Eosinophilic Esophagitis | 600 mg (two 300 mg injections) | 300 mg every week | Subcutaneous injection. Rotate injection sites. |
Dupixent Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 |
| Without Insurance (U.S.) | $3,500 – $3,800 |
| From CPS | $3082.90 |
