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General Medication Fact Sheet for Durezol
| Field | Information |
|---|---|
| Medication Name | Durezol |
| Generic Name | Difluprednate |
| Boxed/Label Warning | Prolonged use may result in glaucoma, with optic nerve damage, visual acuity defects, and posterior subcapsular cataract formation. Steroids should be used with caution in the presence of glaucoma. |
| Purpose | Treatment of inflammation and pain associated with endogenous uveitis and post-operative inflammation following ocular surgery. |
| Mechanism of Action | Corticosteroids, like difluprednate, inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation. |
| Dosage Forms | Ophthalmic Emulsion (Eye Drops) |
| Available Strengths | 0.05% |
| Dosage Frequency | Typically 4 times daily for uveitis; twice daily after cataract surgery, or as directed by a healthcare provider. |
| Common Side Effects | Eye pain, blurred vision, dry eye, foreign body sensation in eye, corneal edema. |
| Serious Side Effects | Increased intraocular pressure (glaucoma), cataract formation, delayed wound healing, secondary ocular infections (bacterial, fungal, viral). |
| Drug Interactions | Other ophthalmic medications, especially steroids; CYP3A4 inhibitors may increase systemic exposure to difluprednate. |
| Important Notes | Do not use if you have an active ocular infection. Long-term use may lead to glaucoma or cataracts. Shake well before using. Consult a doctor if symptoms worsen or do not improve. |
| Storage | Store upright at room temperature away from light and moisture. Do not freeze. |
| Missed Dose | Apply as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. |
| Alternatives | Prednisolone Acetate, Loteprednol Etabonate, Fluorometholone |
Durezol Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Prednisolone Acetate (Pred Forte, Omnipred) | Corticosteroid; reduces inflammation. | A commonly used steroid eye drop for various inflammatory conditions. |
| Loteprednol Etabonate (Lotemax, Eysuvis) | Corticosteroid; reduces inflammation. | Designed to provide effective anti-inflammatory activity with minimal risk of increased intraocular pressure. |
| Fluorometholone (FML) | Corticosteroid; reduces inflammation. | Another steroid eye drop option, often used for milder inflammatory conditions. |
Durezol Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Eye pain | Increased intraocular pressure (glaucoma) |
| Blurred vision | Cataract formation |
| Dry eye | Delayed wound healing |
| Foreign body sensation in eye | Secondary ocular infections (bacterial, fungal, viral) |
| Corneal edema | Optic nerve damage |
Durezol Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Uveitis | 1 drop in the affected eye(s) four times daily | Taper as inflammation subsides | Shake well before using. Use under medical supervision. |
| Post-Operative Inflammation (Cataract Surgery) | 1 drop in the affected eye(s) twice daily | Continue for 2 weeks, starting 24 hours after surgery | Shake well before using. Use under medical supervision. |
Durezol Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 – $50 |
| Without Insurance (U.S.) | $300 – $400 |
| From CPS | $64.95 |
