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General Medication Fact Sheet for Edecrin
| Field | Information |
|---|---|
| Medication Name | Edecrin |
| Generic Name | Ethacrynic Acid |
| Boxed/Label Warning | May cause profound diuresis with water and electrolyte depletion; careful medical supervision required. |
| Purpose | Loop diuretic used to treat edema (fluid retention) associated with heart failure, liver disease, and kidney disease. |
| Mechanism of Action | Inhibits reabsorption of sodium and chloride in the ascending limb of the loop of Henle in the kidney, increasing urine output. |
| Dosage Forms | Oral tablets |
| Available Strengths | 25 mg |
| Dosage Frequency | Usually once or twice daily, as directed by a healthcare provider. |
| Common Side Effects | Nausea, vomiting, diarrhea, abdominal pain, dizziness, headache, blurred vision. |
| Serious Side Effects | Severe dehydration, electrolyte imbalances (low sodium, potassium, magnesium), hearing loss, tinnitus, gout, hyperglycemia. |
| Drug Interactions | Aminoglycoside antibiotics, anticoagulants (e.g., warfarin), digoxin, lithium, NSAIDs, certain blood pressure medications. |
| Important Notes | Regular monitoring of electrolytes and kidney function is crucial. May increase the risk of orthostatic hypotension. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it’s almost time for your next dose. Do not double the dose. Consult your doctor. |
| Alternatives | Furosemide (Lasix), Torsemide (Demadex), Bumetanide (Bumex), Hydrochlorothiazide |
Edecrin Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Furosemide (Lasix) | Loop diuretic; inhibits sodium and chloride reabsorption in the loop of Henle. | Commonly used loop diuretic; shorter duration of action than Torsemide. |
| Torsemide (Demadex) | Loop diuretic; inhibits sodium and chloride reabsorption in the loop of Henle. | Longer duration of action compared to Furosemide. |
| Bumetanide (Bumex) | Loop diuretic; inhibits sodium and chloride reabsorption in the loop of Henle. | More potent than Furosemide; may be useful in patients resistant to other diuretics. |
| Hydrochlorothiazide | Thiazide diuretic; inhibits sodium reabsorption in the distal convoluted tubule. | Less potent diuretic; typically used for mild to moderate fluid retention and hypertension. |
Edecrin Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Severe dehydration |
| Vomiting | Electrolyte imbalances (hyponatremia, hypokalemia, hypomagnesemia) |
| Diarrhea | Hearing loss |
| Abdominal pain | Tinnitus |
| Dizziness | Gout |
| Headache | Hyperglycemia |
| Blurred vision | Orthostatic hypotension |
Edecrin Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Edema (Heart Failure) | 50-100 mg | 25-200 mg daily or every other day | Adjust dosage based on response. May be given once or twice daily. |
| Edema (Liver Disease) | 50-100 mg | 25-200 mg daily or every other day | Adjust dosage based on response. Monitor closely for electrolyte imbalances. |
| Edema (Kidney Disease) | 50-100 mg | 25-200 mg daily or every other day | Adjust dosage based on response and kidney function. |
Edecrin Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 |
| Without Insurance (U.S.) | $240 – $350 |
| From CPS | $175.41 |
