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General Medication Fact Sheet for Emend RX
| Field | Information |
|---|---|
| Medication Name | Emend RX |
| Generic Name | Aprepitant |
| Purpose | Prevention of nausea and vomiting caused by chemotherapy. |
| Mechanism of Action | Neurokinin 1 (NK1) receptor antagonist; blocks substance P binding in the brain. |
| Dosage Forms | Oral capsules, Injection |
| Available Strengths | 40 mg, 80 mg, 125 mg (capsules); 130 mg/mL (injection) |
| Dosage Frequency | Typically a single dose on day 1 of chemotherapy, followed by daily doses on days 2 and 3. |
| Common Side Effects | Fatigue, hiccups, constipation, diarrhea, loss of appetite, headache. |
| Serious Side Effects | Severe allergic reactions (rash, itching, swelling), liver problems, infusion site reactions (with injection). |
| Drug Interactions | Warfarin, oral contraceptives, corticosteroids (e.g., Dexamethasone), chemotherapy drugs (e.g., etoposide, vinblastine), CYP3A4 inhibitors/inducers. |
| Important Notes | Inform your doctor of all medications you are taking; can affect the metabolism of other drugs. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Contact your healthcare provider for instructions if you miss a dose. |
| Alternatives | Dexamethasone, Ondansetron (Zofran), Granisetron, Prochlorperazine. |
Emend RX Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Dexamethasone | Corticosteroid; reduces inflammation and immune response. | Often used in combination with other antiemetics. |
| Ondansetron (Zofran) | Serotonin 5-HT3 receptor antagonist; blocks serotonin in the vomiting center of the brain. | Effective for acute nausea and vomiting. |
| Granisetron | Serotonin 5-HT3 receptor antagonist. | Similar to Ondansetron but may have a longer duration of action. |
| Prochlorperazine | Dopamine antagonist; blocks dopamine receptors in the brain. | May cause drowsiness and extrapyramidal symptoms. |
Emend RX Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Fatigue | Severe allergic reactions (rash, itching, swelling) |
| Hiccups | Liver problems (jaundice, dark urine, abdominal pain) |
| Constipation | Infusion site reactions (pain, swelling, redness – with injection) |
| Diarrhea | Severe dizziness or fainting |
Emend RX Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chemotherapy-Induced Nausea and Vomiting | 125 mg (Day 1) | 80 mg (Days 2 and 3) | Administer 1 hour prior to chemotherapy. |
Emend RX Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 |
| Without Insurance (U.S.) | $400 – $600 |
| From CPS | $107.95 |
