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General Medication Fact Sheet for Enablex
| Field | Information |
|---|---|
| Medication Name | Enablex |
| Generic Name | Darifenacin |
| Purpose | Treatment of overactive bladder with symptoms of urinary frequency, urgency, and urge incontinence. |
| Mechanism of Action | Selective M3 muscarinic receptor antagonist, reducing bladder muscle contractions. |
| Dosage Forms | Extended-release tablets |
| Available Strengths | 7.5 mg, 15 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Dry mouth, constipation, blurred vision, headache |
| Serious Side Effects | Urinary retention, severe constipation, angle-closure glaucoma |
| Drug Interactions | CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir), other anticholinergic medications |
| Important Notes | Use caution in patients with decreased hepatic function. Ensure complete bladder emptying. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Oxybutynin, Tolterodine, Solifenacin, Fesoterodine, Mirabegron |
Enablex Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Oxybutynin (Ditropan) | Non-selective muscarinic receptor antagonist | Available in immediate-release, extended-release, and topical forms. |
| Tolterodine (Detrol) | Muscarinic receptor antagonist | May have fewer side effects than Oxybutynin. |
| Solifenacin (Vesicare) | Selective M3 muscarinic receptor antagonist | Similar mechanism to Enablex, may have different side effect profiles. |
| Fesoterodine (Toviaz) | Muscarinic receptor antagonist (prodrug of Tolterodine) | Converted to Tolterodine in the body. |
| Mirabegron (Myrbetriq) | Beta-3 adrenergic agonist | Relaxes the bladder muscle to increase bladder capacity. Different mechanism than anticholinergics. |
Enablex Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dry mouth | Urinary retention |
| Constipation | Severe constipation |
| Blurred vision | Angle-closure glaucoma |
| Headache | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Dry eyes | Confusion, disorientation, or hallucinations |
Enablex Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Overactive Bladder | 7.5 mg once daily | 7.5 mg to 15 mg once daily | Swallow whole; do not crush or chew. |
Enablex Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 – $50 |
| Without Insurance (U.S.) | $350 – $500 |
| From CPS | $56.95 |
