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General Medication Fact Sheet for Entacapone
| Field | Information |
|---|---|
| Generic Name | Entacapone |
| Brand Name Versions | Comtan |
| Purpose | Used to treat Parkinson’s disease by helping levodopa work more effectively. |
| Mechanism of Action | COMT inhibitor; prevents the breakdown of levodopa in the bloodstream, allowing more levodopa to reach the brain. |
| Dosage Forms | Oral tablets |
| Available Strengths | 200 mg |
| Dosage Frequency | Take with each dose of levodopa/carbidopa, up to a maximum of 8 times daily. |
| Common Side Effects | Dyskinesia (uncontrolled movements), nausea, diarrhea, abdominal pain, urine discoloration (brown-orange). |
| Serious Side Effects | Neuroleptic Malignant Syndrome (NMS), rhabdomyolysis, hallucinations, severe diarrhea. |
| Drug Interactions | MAO inhibitors, certain antidepressants, dopamine agonists, other medications for Parkinson’s disease. |
| Important Notes | Entacapone should only be taken with levodopa/carbidopa. Monitor for changes in mental status or unusual side effects. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | If you miss a dose, take it with your next dose of levodopa/carbidopa. Do not take extra entacapone to make up for a missed dose. |
| Alternatives | Tolcapone, Opicapone, Selegiline, Rasagiline |
Entacapone Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Tolcapone (Tasmar) | COMT inhibitor | Similar to entacapone but with a longer duration of action; requires liver function monitoring. |
| Opicapone (Ongentys) | COMT inhibitor | Taken once daily; helps to prolong the effects of levodopa. |
| Selegiline (Eldepryl) | MAO-B inhibitor | Reduces the breakdown of dopamine in the brain. |
| Rasagiline (Azilect) | MAO-B inhibitor | May be used alone in early Parkinson’s or with levodopa. |
Entacapone Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Dyskinesia (uncontrolled movements) | Neuroleptic Malignant Syndrome (NMS) |
| Nausea | Rhabdomyolysis |
| Diarrhea | Hallucinations |
| Abdominal pain | Severe diarrhea |
| Urine discoloration (brown-orange) | Increased risk of prostate cancer |
Entacapone Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Parkinson’s Disease | 200 mg | 200 mg with each dose of levodopa/carbidopa | Take simultaneously with levodopa/carbidopa; do not exceed 8 doses per day. |
Entacapone Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $150 – $250 |
| From CPS | $29.95 |
