Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
Description
General Medication Fact Sheet for Epclusa
| Field | Information |
|---|---|
| Medication Name | Epclusa |
| Generic Name | Sofosbuvir/Velpatasvir |
| Boxed/Label Warning | Reactivation of Hepatitis B Virus (HBV) has been reported in HCV/HBV co-infected patients who are undergoing or have completed treatment with direct-acting antivirals for HCV and are not receiving HBV antiviral therapy. Screen all patients for evidence of current or prior HBV infection before initiating treatment with Epclusa. HBV reactivation has resulted in serious hepatic outcomes, including fulminant hepatitis, hepatic failure, and death. |
| Purpose | Treatment of chronic hepatitis C virus (HCV) infection in adults. |
| Mechanism of Action | Sofosbuvir inhibits HCV NS5B RNA-dependent RNA polymerase. Velpatasvir inhibits HCV NS5A protein. |
| Dosage Forms | Oral tablets |
| Available Strengths | Sofosbuvir 400 mg/Velpatasvir 100 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Headache, fatigue |
| Serious Side Effects | Hepatitis B virus reactivation, symptomatic bradycardia (when coadministered with amiodarone), liver failure (rare) |
| Drug Interactions | Amiodarone, rifampin, St. John’s Wort, carbamazepine, phenytoin, oxcarbazepine, tipranavir/ritonavir, elbasvir/grazoprevir, cyclosporine, rosuvastatin, digoxin |
| Important Notes | Screen all patients for HBV before starting Epclusa. Avoid coadministration with certain drugs. Consult your doctor about all medications you are taking. |
| Storage | Store at room temperature, between 68°F to 77°F (20°C to 25°C). |
| Missed Dose | Take the missed dose as soon as you remember on the same day. If you don’t remember until the next day, skip the missed dose and go back to your regular schedule. Do not take two doses at once. |
| Alternatives | Mavyret (glecaprevir/pibrentasvir), Harvoni (ledipasvir/sofosbuvir), Vosevi (sofosbuvir/velpatasvir/voxilaprevir) |
Epclusa Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Mavyret (glecaprevir/pibrentasvir) | Glecaprevir inhibits NS3/4A protease; Pibrentasvir inhibits NS5A. | A pan-genotypic treatment option for HCV. |
| Harvoni (ledipasvir/sofosbuvir) | Ledipasvir inhibits NS5A; Sofosbuvir inhibits NS5B polymerase. | Effective for certain genotypes of HCV; Single tablet regimen. |
| Vosevi (sofosbuvir/velpatasvir/voxilaprevir) | Sofosbuvir inhibits NS5B polymerase; Velpatasvir inhibits NS5A; Voxilaprevir inhibits NS3/4A protease. | Used for patients who have failed previous HCV treatment with certain NS5A inhibitors. |
Epclusa Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Hepatitis B virus reactivation |
| Fatigue | Symptomatic bradycardia (when coadministered with amiodarone) |
| Nausea | Liver failure (rare) |
Epclusa Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chronic Hepatitis C (HCV) | Sofosbuvir 400 mg/Velpatasvir 100 mg | Sofosbuvir 400 mg/Velpatasvir 100 mg once daily for 12 weeks | Take with or without food. |
Epclusa Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $500 – $1,500 |
| Without Insurance (U.S.) | $36,000 – $39,000 |
| From CPS | $ |
Why Americans Buy Epclusa from Canada Pharmacy Store?
Why Americans Buy Epclusa from Canada Pharmacy Store?
Americans have trouble affording Epclusa due to numerous factors—but at Canada Pharmacy Store, we offer a safe, affordable alternative. That’s why thousands of Americans trust us to fill their prescriptions with real savings and real service.
Big Savings on U.S. Medications
Our customers save up to 80% on their Epclusa prescriptions compared to U.S. pharmacy prices by ordering through licensed Canadian and international pharmacies.
Free Prescription Transfers
We make it easy! Our pharmacy team can transfer your Epclusa prescriptions directly from your doctor or local pharmacy – completely free of charge.
Direct Access to Experts
Our licensed pharmacists are available to support you, answer your questions, and help ensure you’re confident in your treatment.
Referral Discounts
Spread the word—when you refer friends or family, you both save. It’s our way of saying thanks.
Discreet U.S. Shipping
All orders are packaged discreetly and shipped securely to your U.S. address, with your privacy and safety as top priorities.
Trusted by Americans Nationwide
With years of experience and verified medication sources, we’ve become a go-to solution for Americans looking to cut costs without compromising care.
How to Order Epclusa Online
How to Order Epclusa Online
Step 1
Select Your Prescribed Epclusa Dosage
Choose the strength and quantity as directed by your healthcare provider and add it to your cart.
Step 2
Proceed Through Secure Checkout
Follow the steps to complete your order and provide necessary shipping and payment details.
Step 3
Upload Your Epclusa Prescription
Submit a prescription from a licensed U.S. healthcare provider that matches your order.
At Canada Pharmacy Store, patient safety comes first. We strictly comply with prescription regulations and do not ship any medication without a valid, verifiable prescription. Orders may be declined if a prescription appears falsified or altered in any way. We take these precautions to protect your health and ensure lawful, responsible practices.
Guarantee
Our Guarantee When You Buy Epclusa Through Canada Pharmacy Store
At Canada Pharmacy Store, your safety and satisfaction are our top priorities. We supply only authentic, high-quality medications by working exclusively with licensed Canadian pharmacies and trusted international partners. Every order is filled in accordance with strict regulatory standards and includes medication that’s fully approved by Health Canada or other recognized health authorities such as the MHRA (UK), HSA (Singapore), and the Pharmacy Board of Mauritius.
The Epclusa you receive is the same active medication as what’s available in the U.S.—the only difference is the packaging, which reflects its country of origin. Our licensed healthcare professionals review each order carefully to ensure it matches your prescription exactly.
To get Epclusa at a lower price, simply place your order above or give us a call at 1-888-903-2240
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