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General Medication Fact Sheet for Eplerenone
| Field | Information |
|---|---|
| Generic Name | Eplerenone |
| Brand Name Versions | Inspra |
| Boxed/Label Warning | Eplerenone is contraindicated in patients with hyperkalemia, concomitant treatment with strong CYP3A4 inhibitors, or type 2 diabetes with microalbuminuria. |
| Purpose | Treatment of heart failure after a heart attack; treatment of hypertension. |
| Mechanism of Action | Selective aldosterone receptor antagonist, blocking aldosterone’s effects on sodium and water retention, and potassium excretion. |
| Dosage Forms | Oral tablets |
| Available Strengths | 25 mg, 50 mg |
| Dosage Frequency | Usually once or twice daily, as directed by a healthcare provider |
| Common Side Effects | Hyperkalemia (high potassium), dizziness, fatigue, flu-like symptoms |
| Serious Side Effects | Severe hyperkalemia, allergic reactions (rash, itching, swelling, difficulty breathing), kidney problems |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin), potassium-sparing diuretics, ACE inhibitors, ARBs, lithium |
| Important Notes | Monitor potassium levels regularly; avoid potassium supplements or salt substitutes containing potassium unless directed by a doctor. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Spironolactone, ACE inhibitors, ARBs, Beta-blockers, Diuretics |
Eplerenone Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Spironolactone | Non-selective aldosterone receptor antagonist. | Similar to eplerenone but less selective, which may lead to more side effects. |
| Lisinopril (Prinivil, Zestril) | ACE inhibitor, blocks the conversion of angiotensin I to angiotensin II. | Reduces blood pressure and helps manage heart failure. |
| Losartan (Cozaar) | ARB, blocks the action of angiotensin II. | Reduces blood pressure and helps manage heart failure. |
| Metoprolol (Lopressor, Toprol XL) | Beta-blocker, blocks the effects of adrenaline on the heart. | Reduces heart rate and blood pressure. |
| Furosemide (Lasix) | Loop diuretic, increases urine production. | Reduces fluid retention and blood pressure. |
Eplerenone Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Hyperkalemia (high potassium) | Severe hyperkalemia (muscle weakness, irregular heartbeat) |
| Dizziness | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Fatigue | Kidney problems (decreased urine output, swelling) |
| Flu-like symptoms |
Eplerenone Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Heart Failure Post-MI | 25 mg once daily | 50 mg once daily (target dose) | Monitor potassium levels closely. |
| Hypertension | 50 mg once daily | 50-100 mg daily (once or twice daily) | May be used alone or in combination with other antihypertensive agents. |
Eplerenone Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20-$50 |
| Without Insurance (U.S.) | $50 – $100 |
| From CPS | $41.95 |
