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General Medication Fact Sheet for Esomeprazole
| Field | Information |
|---|---|
| Generic Name | Esomeprazole |
| Brand Name Versions | Nexium |
| Purpose | Proton pump inhibitor (PPI) used to reduce stomach acid |
| Mechanism of Action | Inhibits the H+/K+-ATPase proton pump in gastric parietal cells |
| Dosage Forms | Oral capsules, delayed-release tablets, intravenous |
| Available Strengths | 20 mg, 40 mg |
| Dosage Frequency | Once daily, typically before a meal, or as directed by a healthcare provider |
| Common Side Effects | Headache, diarrhea, nausea, flatulence, abdominal pain |
| Serious Side Effects | Severe allergic reactions, kidney problems, lupus, bone fractures, vitamin B12 deficiency |
| Drug Interactions | Clopidogrel, warfarin, digoxin, methotrexate, certain antifungals (e.g., ketoconazole), HIV medications |
| Important Notes | Take as directed; long-term use may increase the risk of certain side effects; consult a doctor for concerns |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Omeprazole, Pantoprazole, Lansoprazole, Rabeprazole |
Esomeprazole Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Omeprazole (Prilosec) | Proton pump inhibitor | A commonly used PPI, available over-the-counter in some strengths. |
| Pantoprazole (Protonix) | Proton pump inhibitor | Another commonly used PPI, often prescribed for GERD. |
| Lansoprazole (Prevacid) | Proton pump inhibitor | Available both by prescription and over-the-counter. |
| Rabeprazole (AcipHex) | Proton pump inhibitor | A PPI similar in action to other medications in this class. |
Esomeprazole Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Severe allergic reactions (rash, itching, swelling, difficulty breathing) |
| Diarrhea | Kidney problems |
| Nausea | Lupus |
| Flatulence | Bone fractures (hip, wrist, or spine) |
| Abdominal pain | Vitamin B12 deficiency |
Esomeprazole Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| GERD | 20 mg or 40 mg once daily | 20 mg once daily | Take before a meal. |
| Erosive Esophagitis | 20 mg or 40 mg once daily | 20 mg once daily | Take before a meal. |
| Zollinger-Ellison Syndrome | 40 mg twice daily | Adjusted based on acid output | Dosage may vary widely. |
Esomeprazole Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 |
| Without Insurance (U.S.) | $15 – $50 |
| From CPS | $26.95 |
