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General Medication Fact Sheet for Estalis
| Field | Information |
|---|---|
| Medication Name | Estalis |
| Generic Name | Estradiol/Norethindrone Acetate |
| Purpose | Hormone replacement therapy (HRT) to relieve menopausal symptoms |
| Mechanism of Action | Replaces estrogen to alleviate menopausal symptoms; progestin reduces risk of endometrial hyperplasia |
| Dosage Forms | Transdermal patch |
| Available Strengths | Estradiol 50 mcg/Norethindrone Acetate 140 mcg per day; Estradiol 50 mcg/Norethindrone Acetate 250 mcg per day |
| Dosage Frequency | Applied twice weekly (every 3-4 days) |
| Common Side Effects | Headache, breast tenderness, nausea, abdominal pain, back pain |
| Serious Side Effects | Increased risk of blood clots, stroke, heart attack, breast cancer, endometrial cancer |
| Drug Interactions | Anticoagulants (e.g., warfarin), corticosteroids, thyroid hormones, seizure medications (e.g., phenobarbital, phenytoin), St. John’s Wort |
| Important Notes | Use the lowest effective dose for the shortest duration; consult a doctor for individual risk assessment |
| Storage | Store at room temperature, away from moisture and heat. Keep patches in their original packaging until use. |
| Missed Dose | Apply a new patch as soon as you remember, then continue on your regular schedule. Do not apply two patches at the same time. |
| Alternatives | Estradiol (oral, transdermal), Premarin, Progesterone (oral, vaginal) |
Estalis Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Estradiol (various brands and formulations) | Replaces estrogen | Available as oral tablets, transdermal patches, gels, and creams. Used to relieve menopausal symptoms. |
| Premarin (conjugated estrogens) | Replaces estrogen | Derived from natural sources. Used to treat menopausal symptoms. |
| Progesterone (Prometrium, Crinone) | Progestogen; protects the uterus from endometrial hyperplasia | Used in combination with estrogen in women with a uterus to reduce the risk of endometrial cancer. |
| Bijuva (Estradiol and progesterone) | Replaces estrogen and provides progestogen | Oral capsule containing both estrogen and progesterone. |
Estalis Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Blood clots (DVT, pulmonary embolism) |
| Breast tenderness | Stroke |
| Nausea | Heart attack |
| Abdominal pain | Breast cancer |
| Back pain | Endometrial cancer |
| Irritation at the application site | Gallbladder disease |
Estalis Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Menopausal Symptoms | Estradiol 50 mcg/Norethindrone Acetate 140 mcg or 250 mcg patch | Adjusted by physician based on symptom relief and tolerance | Apply patch to clean, dry skin on the abdomen or upper buttocks, avoiding the waistline. Rotate application sites. Do not apply to oily, damaged, or irritated skin. |
Estalis Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 – $50 |
| Without Insurance (U.S.) | $250 – $350 |
| From CPS | $48.95 |
