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General Medication Fact Sheet for Estrace
| Field | Information |
|---|---|
| Medication Name | Estrace |
| Generic Name | Estradiol |
| Boxed/Label Warning | Estrogen-Alone Therapy: Increased risk of endometrial cancer, stroke, and dementia. Estrogen Plus Progestin Therapy: Increased risk of stroke, heart attack, breast cancer, and blood clots. |
| Purpose | Hormone replacement therapy to treat menopausal symptoms (e.g., hot flashes, vaginal dryness) and hypoestrogenism. |
| Mechanism of Action | Replaces estrogen, binding to estrogen receptors to alleviate symptoms associated with estrogen deficiency. |
| Dosage Forms | Oral tablets, Vaginal Cream |
| Available Strengths | Oral Tablets: 0.5 mg, 1 mg, 2 mg. Vaginal Cream: 0.01% |
| Dosage Frequency | Oral: Typically once daily. Vaginal Cream: As directed by a healthcare provider. |
| Common Side Effects | Nausea, headache, breast tenderness, bloating, vaginal bleeding or spotting. |
| Serious Side Effects | Blood clots, stroke, heart attack, breast cancer, endometrial cancer, gallbladder disease, high blood pressure. |
| Drug Interactions | Anticoagulants (e.g., warfarin), thyroid hormones, corticosteroids, St. John’s Wort, certain antifungals (e.g., ketoconazole). |
| Important Notes | Use the lowest effective dose for the shortest duration. Regular check-ups and mammograms are recommended. Inform your doctor of any history of blood clots, heart disease, or cancer. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember, unless it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Premarin, Estradiol Transdermal Patch (e.g., Climara, Vivelle-Dot), Vagifem (estradiol vaginal tablets), Imvexxy (estradiol vaginal inserts). |
Estrace Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Premarin (conjugated estrogens) | Replaces estrogen, binding to estrogen receptors to alleviate symptoms associated with estrogen deficiency. | Derived from natural sources; available in various forms. |
| Estradiol Transdermal Patch (Climara, Vivelle-Dot) | Replaces estrogen, binding to estrogen receptors to alleviate symptoms associated with estrogen deficiency. | Delivers estrogen through the skin, providing a steady dose. |
| Vagifem (estradiol vaginal tablets) | Replaces estrogen locally in the vagina. | Used specifically for vaginal atrophy and dryness. |
| Imvexxy (estradiol vaginal inserts) | Replaces estrogen locally in the vagina. | Another option for treating vaginal atrophy. |
Estrace Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Blood clots (DVT, PE) |
| Headache | Stroke |
| Breast tenderness | Heart attack |
| Bloating | Breast cancer |
| Vaginal bleeding or spotting | Endometrial cancer |
| Mood changes | Gallbladder disease |
Estrace Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Menopausal Symptoms (e.g., hot flashes) | 0.5 mg daily | 0.5-2 mg daily | Adjust dose based on symptom control. |
| Vaginal Atrophy | 0.5 mg daily | 0.5-1 mg daily | May use vaginal cream as an alternative. |
| Hypoestrogenism | 0.5 mg three times daily | 0.5-2 mg daily, divided doses | Adjust dose based on hormone levels. |
Estrace Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 – $40 |
| Without Insurance (U.S.) | $120 – $200 |
| From CPS | $59.95 |
