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General Medication Fact Sheet for Estraderm
| Field | Information |
|---|---|
| Medication Name | Estraderm |
| Generic Name | Estradiol |
| Boxed/Label Warning | Estrogens increase the risk of endometrial cancer, stroke, deep vein thrombosis, pulmonary embolism, and dementia. Use at the lowest effective dose for the shortest duration. |
| Purpose | Hormone replacement therapy to treat moderate to severe vasomotor symptoms (hot flashes) and vulvar and vaginal atrophy associated with menopause. |
| Mechanism of Action | Replaces estrogen that the body no longer produces, reducing menopausal symptoms. |
| Dosage Forms | Transdermal patch |
| Available Strengths | 0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, 0.1 mg/day |
| Dosage Frequency | Applied to the skin twice weekly or as directed by a healthcare provider. |
| Common Side Effects | Headache, breast tenderness, nausea, skin irritation at application site, vaginal bleeding |
| Serious Side Effects | Blood clots, stroke, heart attack, breast cancer, endometrial cancer, gallbladder disease, high blood pressure |
| Drug Interactions | Thyroid medications, anticoagulants (e.g., warfarin), corticosteroids, St. John’s Wort |
| Important Notes | Apply to clean, dry, intact skin of the abdomen or buttocks, avoiding oily, damaged, or irritated areas. Rotate application sites. Have regular checkups with your doctor. |
| Storage | Store at room temperature in a cool, dry place, away from light and moisture. Keep patches in their original packaging until use. |
| Missed Dose | Apply a new patch as soon as you remember. Change the patch on your regularly scheduled day. Do not double the dose. |
| Alternatives | Estrace (estradiol), Premarin (conjugated estrogens), Climara (estradiol), Vivelle-Dot (estradiol) |
Estraderm Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Estrace (estradiol) | Estrogen receptor agonist | Available as a tablet and vaginal cream for treatment of menopausal symptoms. |
| Premarin (conjugated estrogens) | Estrogen receptor agonist | A mixture of estrogen hormones used to treat menopausal symptoms and prevent osteoporosis. |
| Climara (estradiol) | Estrogen receptor agonist | Transdermal patch similar to Estraderm, delivering estradiol through the skin. |
| Vivelle-Dot (estradiol) | Estrogen receptor agonist | Another transdermal patch option for estrogen replacement therapy. |
Estraderm Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Blood clots (DVT, pulmonary embolism) |
| Breast tenderness | Stroke |
| Nausea | Heart attack |
| Skin irritation at application site | Breast cancer |
| Vaginal bleeding | Endometrial cancer |
Estraderm Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Vasomotor Symptoms (Hot Flashes) | 0.025 mg/day or 0.05 mg/day | Adjusted based on symptom relief and tolerance | Apply patch to clean, dry skin of abdomen or buttocks twice weekly. Rotate application sites. |
| Vulvar and Vaginal Atrophy | 0.025 mg/day | Adjusted based on symptom relief and tolerance | Apply patch to clean, dry skin of abdomen or buttocks twice weekly. Rotate application sites. |
Estraderm Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 – $50 |
| Without Insurance (U.S.) | $250 – $350 |
| From CPS | $8.80 |
