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General Medication Fact Sheet for Estring Vaginal Rings
| Field | Information |
|---|---|
| Medication Name | Estring Vaginal Rings |
| Generic Name | Estradiol |
| Purpose | Treats moderate to severe vaginal dryness, itching, and painful intercourse caused by menopause. |
| Mechanism of Action | Releases estradiol, a form of estrogen, directly into the vaginal tissue, helping to restore its thickness and elasticity. |
| Dosage Forms | Vaginal ring |
| Available Strengths | 2 mg estradiol (releases approximately 7.5 mcg/day) |
| Dosage Frequency | One ring inserted into the vagina, replaced every 90 days. |
| Common Side Effects | Vaginal discomfort, vaginal discharge, headache, breast tenderness, nausea. |
| Serious Side Effects | Unusual vaginal bleeding, blood clots, stroke, heart attack, breast cancer, endometrial cancer. |
| Drug Interactions | Aromatase inhibitors (e.g., anastrozole), tamoxifen, corticosteroids, thyroid hormones. |
| Important Notes | Inform your doctor if you have a history of blood clots, stroke, heart disease, breast cancer, or endometrial cancer. Regular check-ups are necessary while using this medication. |
| Storage | Store at room temperature. Keep the ring in its original packaging until ready to use. |
| Missed Dose | This medication is a vaginal ring inserted and replaced every 90 days as directed by your healthcare provider. |
| Alternatives | Vagifem (estradiol vaginal tablets), Imvexxy (estradiol vaginal inserts), Premarin Vaginal Cream (conjugated estrogens), Osphena (ospemifene). |
Estring Vaginal Rings Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Vagifem (estradiol vaginal tablets) | Estrogen receptor agonist | Tablets inserted into the vagina to deliver estrogen locally. |
| Imvexxy (estradiol vaginal inserts) | Estrogen receptor agonist | Softgel inserts that deliver a low dose of estrogen to the vagina. |
| Premarin Vaginal Cream (conjugated estrogens) | Estrogen receptor agonist | Topical estrogen cream applied to the vagina. |
| Osphena (ospemifene) | Selective estrogen receptor modulator (SERM) | Oral medication that acts like estrogen in the vaginal tissue. |
Estring Vaginal Rings Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Vaginal discomfort | Unusual vaginal bleeding |
| Vaginal discharge | Blood clots |
| Headache | Stroke |
| Breast tenderness | Heart attack |
| Nausea | Breast cancer |
| Back pain | Endometrial cancer |
Estring Vaginal Rings Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Vaginal Atrophy | One vaginal ring | Replace ring every 90 days | Insert the ring into the vagina as directed by your healthcare provider. The ring should be left in place continuously for 90 days. |



