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General Medication Fact Sheet for Estrofem
| Field | Information |
|---|---|
| Medication Name | Estrofem |
| Generic Name | Estradiol |
| Boxed/Label Warning | Estrogen-alone therapy should not be used to prevent heart disease or dementia. Estrogen with progestin therapy may increase the risk of heart attack, stroke, invasive breast cancer, blood clots and dementia. |
| Purpose | Hormone replacement therapy (HRT) to treat menopausal symptoms such as hot flashes, vaginal dryness, and to prevent osteoporosis. |
| Mechanism of Action | Replaces estrogen, a hormone naturally produced by the body. Estrogen binds to estrogen receptors, influencing gene expression and cellular function in various tissues. |
| Dosage Forms | Oral tablets |
| Available Strengths | 1 mg, 2 mg |
| Dosage Frequency | Typically once daily, or as directed by a healthcare provider |
| Common Side Effects | Nausea, headache, breast tenderness, vaginal bleeding or spotting, bloating |
| Serious Side Effects | Blood clots, stroke, heart attack, breast cancer, endometrial cancer, gallbladder disease |
| Drug Interactions | Warfarin, thyroid hormones, corticosteroids, certain antibiotics (e.g., rifampin), anticonvulsants (e.g., phenobarbital) |
| Important Notes | Inform your doctor about any history of blood clots, heart disease, cancer, or liver problems. Regular check-ups are crucial. |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Premarin (conjugated estrogens), Estradiol transdermal patch (Climara, Vivelle-Dot), Bazedoxifene/conjugated estrogens (Duavee), Generic Estradiol tablets |
Estrofem Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Premarin (conjugated estrogens) | Mixture of estrogen hormones | Derived from natural sources; used for hormone replacement therapy. |
| Estradiol transdermal patch (Climara, Vivelle-Dot) | Estradiol | Delivers estrogen through the skin, providing a steady dose. |
| Bazedoxifene/conjugated estrogens (Duavee) | Estrogen agonist/antagonist | Combines estrogen with a selective estrogen receptor modulator (SERM). |
| Generic Estradiol tablets | Estradiol | A more affordable option providing the same active ingredient. |
Estrofem Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Blood clots (DVT, pulmonary embolism) |
| Headache | Stroke |
| Breast tenderness | Heart attack |
| Vaginal bleeding or spotting | Breast cancer |
| Bloating | Endometrial cancer |
| Mood changes | Gallbladder disease |
Estrofem Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Menopausal Symptoms | 1 mg daily | 1-2 mg daily | Take orally once a day. |
| Prevention of Osteoporosis | 0.5 mg daily | 0.5-1 mg daily | Take orally once a day. |
Estrofem Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $10 – $40 |
| Without Insurance (U.S.) | $120 – $200 |
| From CPS | $ |
