Notice: Images are for illustration only and may not reflect the exact product you receive. Brand-name medications may look different depending on their country of origin—Canadian versions, for example, often include a "PR" symbol on the packaging. Rest assured, the medication, dosage, and active ingredients will be exactly as prescribed. Canada Pharmacy Store is committed to your health and safety, and we work only with licensed pharmacies to ensure you receive trusted, high-quality medication every time.
General Medication Fact Sheet for Estrogel
| Field | Information |
|---|---|
| Medication Name | Estrogel |
| Generic Name | Estradiol (topical) |
| Boxed/Label Warning | Estrogen-Alone Therapy: Endometrial Cancer, Cardiovascular Disorders, and Probable Dementia. Estrogen Plus Progestin Therapy: Cardiovascular Disorders, Breast Cancer, and Probable Dementia. |
| Purpose | Hormone replacement therapy (HRT) to treat moderate to severe vasomotor symptoms (e.g., hot flashes) associated with menopause. |
| Mechanism of Action | Replaces estrogen, a hormone that declines during menopause, thereby alleviating symptoms related to estrogen deficiency. |
| Dosage Forms | Topical gel |
| Available Strengths | 0.06% estradiol |
| Dosage Frequency | Typically applied once daily, or as directed by a healthcare provider. |
| Common Side Effects | Application site reactions (irritation, redness), breast tenderness, headache, nausea, vaginal bleeding. |
| Serious Side Effects | Increased risk of blood clots, stroke, heart attack, endometrial cancer, breast cancer. |
| Drug Interactions | Certain medications can affect estradiol levels, including some antibiotics (e.g., rifampin), antifungals (e.g., ketoconazole), and HIV medications. |
| Important Notes | Apply to clean, dry, intact skin. Avoid application to the breasts. Consult a doctor if you have a history of blood clots, heart disease, or certain cancers. Periodic monitoring is required. |
| Storage | Store at room temperature away from heat and moisture. Keep out of reach of children. |
| Missed Dose | Apply as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. |
| Alternatives | Estrace (estradiol), Premarin (conjugated estrogens), Climara (estradiol transdermal patch), Divigel (estradiol topical gel) |
Estrogel Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Estrace (estradiol) | Replaces estrogen, alleviating menopausal symptoms. | Oral tablet; can be used for various estrogen deficiency symptoms. |
| Premarin (conjugated estrogens) | Replaces estrogen, alleviating menopausal symptoms. | Oral tablet containing a mixture of estrogens. |
| Climara (estradiol transdermal patch) | Replaces estrogen through skin absorption. | Patch applied to the skin; provides continuous estrogen release. |
| Divigel (estradiol topical gel) | Replaces estrogen through skin absorption. | Similar to Estrogel, another topical estradiol gel. |
Estrogel Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Application site reactions (redness, irritation) | Increased risk of blood clots (DVT, pulmonary embolism) |
| Breast tenderness | Stroke |
| Headache | Heart attack |
| Nausea | Endometrial cancer |
| Vaginal bleeding or spotting | Breast cancer |
| Mood changes | Gallbladder disease |
Estrogel Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Vasomotor Symptoms (Hot Flashes) | Usually 1.25 g of gel (0.75 mg estradiol) | Adjusted based on symptom control, typically 0.5 g to 1.25 g daily | Apply to clean, dry skin on the arm or shoulder once daily. Do not apply to breasts or vaginal area. |
Estrogel Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 – $25 |
| Without Insurance (U.S.) | $200 – $300 |
| From CPS | $36.95 |
