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General Medication Fact Sheet for Everolimus
| Field | Information |
|---|---|
| Generic Name | Everolimus |
| Brand Name Versions | Afinitor, Zortress |
| Boxed/Label Warning | Increased susceptibility to infection and the possible development of lymphomas and other cancers, skin cancer. |
| Purpose | Immunosuppressant and antineoplastic agent used to prevent organ rejection after transplant and to treat certain cancers. |
| Mechanism of Action | Inhibits mTOR (mammalian target of rapamycin), a protein kinase that regulates cell growth, proliferation, and survival. |
| Dosage Forms | Oral tablets |
| Available Strengths | 0.25 mg, 0.5 mg, 0.75 mg, 2.5 mg, 5 mg, 10 mg |
| Dosage Frequency | Typically once daily, or as directed by a healthcare provider. |
| Common Side Effects | Mouth ulcers, infections, rash, fatigue, diarrhea, nausea, decreased appetite, swelling in the extremities. |
| Serious Side Effects | Severe infections, kidney problems, lung problems, wound healing complications, high blood sugar, high cholesterol, allergic reactions. |
| Drug Interactions | Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole), strong CYP3A4 inducers (e.g., rifampin, phenytoin), Cyclosporine. |
| Important Notes | Regular blood tests are required to monitor kidney function, blood counts, and cholesterol levels; avoid grapefruit and grapefruit juice. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. |
| Alternatives | Sirolimus, Tacrolimus, Cyclosporine, Prednisone |
Everolimus Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Sirolimus (Rapamune) | mTOR inhibitor | Used for immunosuppression, similar to everolimus. |
| Tacrolimus (Prograf) | Calcineurin inhibitor | Another immunosuppressant used to prevent organ rejection. |
| Cyclosporine (Neoral, Sandimmune) | Calcineurin inhibitor | Immunosuppressant used to prevent organ rejection and treat certain autoimmune diseases. |
| Prednisone (Deltasone) | Corticosteroid | Used for its anti-inflammatory and immunosuppressant effects. |
Everolimus Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Mouth ulcers | Severe infections |
| Infections | Kidney problems |
| Rash | Lung problems |
| Fatigue | Wound healing complications |
| Diarrhea | High blood sugar |
| Nausea | High cholesterol |
| Decreased appetite | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Swelling in the extremities |
Everolimus Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Renal Cell Carcinoma | 10 mg | 10 mg once daily | Take consistently with or without food. |
| Pancreatic Neuroendocrine Tumors | 10 mg | 10 mg once daily | Take consistently with or without food. |
| Tuberous Sclerosis Complex (TSC) | Individualized | Individualized, based on body surface area and trough levels. | Monitor trough levels regularly. |
| Organ Transplant Rejection | Individualized | Individualized, based on trough levels and clinical response. | Administer with other immunosuppressants. |
Everolimus Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 |
| Without Insurance (U.S.) | $1,000 – $2,000 |
| From CPS | $ |
