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General Medication Fact Sheet for Evotaz
| Field | Information |
|---|---|
| Medication Name | Evotaz |
| Generic Name | Atazanavir/Cobicistat |
| Boxed/Label Warning | Risk of serious and potentially fatal liver problems. |
| Purpose | Antiretroviral medication used to treat HIV-1 infection |
| Mechanism of Action | Atazanavir inhibits HIV-1 protease; Cobicistat inhibits CYP3A enzymes to increase atazanavir levels |
| Dosage Forms | Oral tablets |
| Available Strengths | 300 mg atazanavir/150 mg cobicistat |
| Dosage Frequency | Once daily |
| Common Side Effects | Nausea, diarrhea, headache, fatigue, jaundice (yellowing of the skin or eyes) |
| Serious Side Effects | Severe skin reactions, liver problems, kidney problems, changes in heart rhythm |
| Drug Interactions | Many medications interact with Evotaz; consult your healthcare provider or pharmacist |
| Important Notes | Take with food; do not take with certain other medications; monitor liver function |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember unless it is close to your next scheduled dose. Do not double dose. |
| Alternatives | Darunavir/Cobicistat (Prezcobix), Elvitegravir/Cobicistat/Emtricitabine/Tenofovir alafenamide (Genvoya), Bictegravir/Emtricitabine/Tenofovir alafenamide (Biktarvy) |
Evotaz Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Darunavir/Cobicistat (Prezcobix) | Darunavir: HIV-1 protease inhibitor; Cobicistat: CYP3A inhibitor | Another protease inhibitor boosted with cobicistat. |
| Elvitegravir/Cobicistat/Emtricitabine/Tenofovir alafenamide (Genvoya) | Elvitegravir: Integrase strand transfer inhibitor; Cobicistat: CYP3A inhibitor; Emtricitabine & Tenofovir alafenamide: NRTI | A single-tablet regimen containing an integrase inhibitor and two NRTIs boosted with cobicistat. |
| Bictegravir/Emtricitabine/Tenofovir alafenamide (Biktarvy) | Bictegravir: Integrase strand transfer inhibitor; Emtricitabine & Tenofovir alafenamide: NRTI | A single-tablet regimen containing an integrase inhibitor and two NRTIs. |
Evotaz Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) |
| Diarrhea | Liver problems (hepatitis, liver failure) |
| Headache | Kidney problems (kidney failure) |
| Fatigue | Changes in heart rhythm (QT prolongation) |
| Jaundice (yellowing of the skin or eyes) | New or worsening diabetes |
Evotaz Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| HIV-1 Infection | One tablet | One tablet once daily | Take with food. Do not take with certain other medications. |
