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General Medication Fact Sheet for Evra
| Field | Information |
|---|---|
| Medication Name | Evra |
| Generic Name | Norelgestromin and Ethinyl Estradiol |
| Boxed/Label Warning | Cigarette smoking increases the risk of serious cardiovascular side effects from hormonal contraceptive use. Women who use hormonal contraceptives are strongly advised not to smoke. Hormonal contraceptives are contraindicated in women with current or history of thrombosis or thromboembolic disorders. |
| Purpose | Hormonal contraceptive patch used to prevent pregnancy. |
| Mechanism of Action | Suppresses ovulation by releasing synthetic estrogen (ethinyl estradiol) and progestin (norelgestromin), which inhibit the release of gonadotropins (LH and FSH). |
| Dosage Forms | Transdermal patch |
| Available Strengths | 6 mg norelgestromin/0.75 mg ethinyl estradiol per 20 cm² patch |
| Dosage Frequency | One patch applied weekly for three weeks, followed by one week off. |
| Common Side Effects | Headache, nausea, breast tenderness, application site reactions, mood changes. |
| Serious Side Effects | Blood clots, stroke, heart attack, high blood pressure, liver problems, gallbladder disease. |
| Drug Interactions | Certain antibiotics (e.g., rifampin), antifungals (e.g., griseofulvin), anti-seizure medications (e.g., phenytoin, carbamazepine), HIV protease inhibitors, St. John’s Wort. |
| Important Notes | Do not use if you have a history of blood clots, stroke, heart attack, or certain types of cancer. Consult your doctor if you have risk factors for heart disease. |
| Storage | Store at room temperature, away from heat and moisture. Keep unused patches in their original pouch. |
| Missed Dose | If the patch is detached for less than 24 hours, reapply it immediately. If detached for more than 24 hours, start a new patch cycle. Use non-hormonal contraception (e.g., condoms) for 7 days. |
| Alternatives | Oral contraceptives (e.g., Lo Loestrin Fe, Yasmin), NuvaRing, Depo-Provera, Mirena IUD. |
Evra Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Lo Loestrin Fe (ethinyl estradiol/norethindrone acetate) | Oral contraceptive: Suppresses ovulation. | Low-dose oral contraceptive pill. |
| Yasmin (drospirenone/ethinyl estradiol) | Oral contraceptive: Suppresses ovulation. | Oral contraceptive pill; contains drospirenone, a progestin with anti-androgenic properties. |
| NuvaRing (etonogestrel/ethinyl estradiol) | Vaginal ring: Suppresses ovulation. | Vaginal ring that releases hormones. |
| Depo-Provera (medroxyprogesterone acetate) | Injectable progestin: Inhibits ovulation. | Injectable contraceptive administered every 3 months. |
| Mirena IUD (levonorgestrel) | Intrauterine device: Thickens cervical mucus and may inhibit ovulation. | Long-acting reversible contraception; inserted into the uterus. |
Evra Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Blood clots (DVT, pulmonary embolism) |
| Nausea | Stroke |
| Breast tenderness | Heart attack |
| Application site reactions (itching, redness) | High blood pressure |
| Mood changes | Liver problems (e.g., liver tumors) |
| Menstrual changes | Gallbladder disease |
Evra Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Contraception | One patch | One patch weekly for 3 weeks, then one week off. | Apply to clean, dry skin on the abdomen, buttocks, upper outer arm, or back. Do not apply to irritated skin. |
Evra Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30 |
| Without Insurance (U.S.) | $120 – $180 |
| From CPS | $54.95 |
