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General Medication Fact Sheet for Exjade
| Field | Information |
|---|---|
| Medication Name | Exjade |
| Generic Name | Deferasirox |
| Boxed/Label Warning | Possible kidney, liver, and gastrointestinal complications, sometimes fatal. Patients should be monitored regularly. |
| Purpose | Iron chelator used to reduce iron overload in patients receiving chronic blood transfusions |
| Mechanism of Action | Binds to iron and forms a complex that is excreted through the feces |
| Dosage Forms | Oral tablets for suspension |
| Available Strengths | 125 mg, 250 mg, 500 mg |
| Dosage Frequency | Once daily, usually before a meal |
| Common Side Effects | Nausea, vomiting, diarrhea, abdominal pain, rash, increased creatinine |
| Serious Side Effects | Kidney problems, liver problems, gastrointestinal bleeding, hearing loss, vision disturbances, Stevens-Johnson syndrome |
| Drug Interactions | Aluminum-containing antacids, repaglinide, theophylline, certain antibiotics (e.g., rifampin), phenytoin, cyclosporine |
| Important Notes | Take on an empty stomach or with a light meal; avoid taking with aluminum-containing antacids; regular monitoring of kidney and liver function is essential. |
| Storage | Store at room temperature, away from moisture and light. Keep the container tightly closed. |
| Missed Dose | Take the missed dose as soon as you remember. If it is close to your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose. |
| Alternatives | Desferal (deferoxamine), Ferriprox (deferiprone) |
Exjade Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Desferal (deferoxamine) | Binds to iron and forms a complex that is excreted via the kidneys | Administered by injection or infusion; requires a dedicated infusion pump. |
| Ferriprox (deferiprone) | Binds to iron in the bloodstream and removes it from the body through urine | Oral medication; associated with a risk of agranulocytosis (low white blood cell count). |
Exjade Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Kidney problems (renal failure) |
| Vomiting | Liver problems (hepatic failure) |
| Diarrhea | Gastrointestinal bleeding |
| Abdominal Pain | Hearing loss |
| Rash | Vision disturbances |
| Increased Creatinine | Stevens-Johnson Syndrome |
Exjade Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Iron Overload Due to Transfusions | 20 mg/kg daily | Adjusted based on serum ferritin levels, usually between 20-40 mg/kg daily | Take once daily on an empty stomach or with a light meal. Disperse tablets in water, apple juice, or orange juice immediately before use. |
Exjade Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $300 – $400 |
| Without Insurance (U.S.) | $3,000 – $13,000 |
| From CPS | $243.95 |
