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General Medication Fact Sheet for Ezetimibe
| Field | Information |
|---|---|
| Generic Name | Ezetimibe |
| Brand Name Versions | Zetia |
| Purpose | Lowers cholesterol levels in the blood |
| Mechanism of Action | Inhibits the absorption of cholesterol in the small intestine |
| Dosage Forms | Oral tablets |
| Available Strengths | 10 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Headache, fatigue, abdominal pain, diarrhea |
| Serious Side Effects | Muscle pain/weakness (rhabdomyolysis), liver problems, allergic reactions |
| Drug Interactions | Statins (e.g., Atorvastatin, Simvastatin), fibrates (e.g., Gemfibrozil), bile acid sequestrants (e.g., cholestyramine), cyclosporine |
| Important Notes | Inform your doctor of all medications you are taking; liver function tests may be needed periodically |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Statins (Atorvastatin, Simvastatin), Bile Acid Sequestrants (Cholestyramine), Fibrates (Gemfibrozil), PCSK9 Inhibitors (Evolocumab) |
Ezetimibe Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Atorvastatin (Lipitor) | HMG-CoA reductase inhibitor (statin) | Reduces cholesterol production in the liver. |
| Simvastatin (Zocor) | HMG-CoA reductase inhibitor (statin) | Reduces cholesterol production in the liver. |
| Cholestyramine (Questran) | Bile acid sequestrant | Binds to bile acids in the intestine, preventing their reabsorption and promoting cholesterol breakdown. |
| Gemfibrozil (Lopid) | Fibrate | Primarily lowers triglycerides and raises HDL cholesterol. |
| Evolocumab (Repatha) | PCSK9 inhibitor | Inhibits PCSK9, leading to more LDL receptors on liver cells to clear cholesterol. |
Ezetimibe Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Muscle pain/weakness (rhabdomyolysis) |
| Fatigue | Liver problems |
| Abdominal pain | Allergic reactions (rash, itching, swelling, difficulty breathing) |
| Diarrhea | Elevated liver enzymes |
Ezetimibe Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| High Cholesterol | 10 mg | 10 mg daily | May be taken with or without food. |
| Familial Hypercholesterolemia | 10 mg | 10 mg daily | May be used alone or in combination with a statin. |
| Sitosterolemia | 10 mg | 10 mg daily | Take consistently each day. |
Ezetimibe Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 |
| Without Insurance (U.S.) | $15 – $40 |
| From CPS | $7.32 |
