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General Medication Fact Sheet for Fenofibrate
| Field | Information |
|---|---|
| Generic Name | Fenofibrate |
| Brand Name Versions | Tricor, Trilipix, Antara, Lipofen |
| Purpose | Used to lower cholesterol and triglycerides in the blood. |
| Mechanism of Action | Activates peroxisome proliferator-activated receptor alpha (PPARα), which increases the breakdown of triglycerides and increases HDL cholesterol. |
| Dosage Forms | Oral capsules and tablets |
| Available Strengths | 43 mg, 45 mg, 50 mg, 67 mg, 134 mg, 135 mg, 145 mg, 150 mg, 160 mg |
| Dosage Frequency | Typically once daily, or as directed by a healthcare provider |
| Common Side Effects | Abdominal pain, back pain, headache, nausea, constipation, runny nose. |
| Serious Side Effects | Muscle pain or weakness (rhabdomyolysis), liver problems, gallbladder problems, pancreatitis, blood clots. |
| Drug Interactions | Statins (e.g., Atorvastatin, simvastatin), blood thinners (e.g., warfarin), bile acid sequestrants (e.g., cholestyramine), colchicine. |
| Important Notes | May increase the risk of muscle damage when taken with statins. Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. Take with food to improve absorption. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; skip if it’s almost time for your next dose. Do not double the dose. |
| Alternatives | Gemfibrozil, Atorvastatin, Rosuvastatin, Ezetimibe |
Fenofibrate Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Gemfibrozil (Lopid) | Activates PPARα, similar to fenofibrate. | Another fibrate medication. May have different drug interaction profiles. |
| Atorvastatin (Lipitor) | HMG-CoA reductase inhibitor (statin). | Lowers LDL cholesterol primarily. May be used in combination with fenofibrate. |
| Rosuvastatin (Crestor) | HMG-CoA reductase inhibitor (statin). | Another statin medication. Lowers LDL cholesterol primarily. May be used in combination with fenofibrate. |
| Ezetimibe (Zetia) | Inhibits cholesterol absorption in the small intestine. | Lowers LDL cholesterol. Can be used alone or in combination with a statin. |
Fenofibrate Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Abdominal pain | Muscle pain or weakness (rhabdomyolysis) |
| Back pain | Liver problems |
| Headache | Gallbladder problems |
| Nausea | Pancreatitis |
| Constipation | Blood clots |
Fenofibrate Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Hypertriglyceridemia | 43-50 mg daily | 43-160 mg daily, depending on formulation | Take with food. Dosage adjusted based on triglyceride levels. |
| Mixed Dyslipidemia | 134-150 mg daily | 134-200 mg daily, depending on formulation | Take with food. Dosage adjusted based on lipid panel results. |
Fenofibrate Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $20 |
| Without Insurance (U.S.) | $15 – $60 |
| From CPS | $30 |
