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General Medication Fact Sheet for Fetzima
| Field | Information |
|---|---|
| Medication Name | Fetzima |
| Generic Name | Levomilnacipran |
| Boxed/Label Warning | May increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults. |
| Purpose | Treatment of major depressive disorder (MDD). |
| Mechanism of Action | Selective serotonin and norepinephrine reuptake inhibitor (SNRI). |
| Dosage Forms | Extended-release capsules |
| Available Strengths | 20 mg, 40 mg, 80 mg, 120 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Nausea, constipation, hyperhidrosis (excessive sweating), erectile dysfunction, increased heart rate, palpitations, vomiting, tachycardia, heart rate increased and blood pressure increased. |
| Serious Side Effects | Increased blood pressure, serotonin syndrome, angle-closure glaucoma, abnormal bleeding, suicidal thoughts/behavior, withdrawal symptoms if discontinued abruptly. |
| Drug Interactions | MAOIs, other SNRIs/SSRIs, triptans, tramadol, linezolid, lithium, St. John’s Wort, NSAIDs, anticoagulants. |
| Important Notes | Monitor for worsening depression or suicidal thoughts; avoid abrupt discontinuation; may cause increased blood pressure. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember unless it is almost time for your next dose. Do not double the dose. |
| Alternatives | Pristiq (desvenlafaxine), Cymbalta (duloxetine), Effexor (venlafaxine), Sertraline, Fluoxetine. |
Fetzima Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Pristiq (desvenlafaxine) | SNRI | Another SNRI antidepressant. |
| Cymbalta (duloxetine) | SNRI | SNRI also approved for pain conditions. |
| Effexor (venlafaxine) | SNRI | Older SNRI with potential for withdrawal symptoms. |
| Sertraline | SSRI | A commonly prescribed SSRI antidepressant. |
| Fluoxetine | SSRI | An SSRI with a longer half-life. |
Fetzima Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Increased blood pressure |
| Constipation | Serotonin syndrome |
| Hyperhidrosis (excessive sweating) | Angle-closure glaucoma |
| Erectile dysfunction | Abnormal bleeding |
| Increased heart rate | Suicidal thoughts/behavior |
| Vomiting | Withdrawal symptoms |
Fetzima Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Major Depressive Disorder (MDD) | 20 mg once daily | 40-120 mg once daily | Swallow capsules whole; do not crush or chew. |
Fetzima Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30 – $100 |
| Without Insurance (U.S.) | $450 – $550 |
| From CPS | $147.95 |
