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General Medication Fact Sheet for Gefitinib
| Field | Information |
|---|---|
| Generic Name | Gefitinib |
| Brand Name Versions | Iressa |
| Purpose | Treatment of non-small cell lung cancer (NSCLC) with specific EGFR mutations |
| Mechanism of Action | Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitor |
| Dosage Forms | Oral tablets |
| Available Strengths | 250 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Diarrhea, rash, dry skin, nausea, vomiting, loss of appetite, mouth sores |
| Serious Side Effects | Interstitial lung disease (ILD), liver problems, severe skin reactions, corneal ulceration |
| Drug Interactions | CYP3A4 inhibitors (e.g., ketoconazole), CYP3A4 inducers (e.g., rifampin), warfarin |
| Important Notes | EGFR mutation testing is required before starting treatment; report any new or worsening respiratory symptoms immediately |
| Storage | Store at room temperature away from moisture and light |
| Missed Dose | Take as soon as you remember unless it is close to your next dose. Do not double the dose. |
| Alternatives | Erlotinib, Afatinib, Osimertinib |
Gefitinib Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Erlotinib (Tarceva) | EGFR tyrosine kinase inhibitor | Similar to Gefitinib, used for NSCLC with EGFR mutations. |
| Afatinib (Gilotrif) | Irreversible EGFR tyrosine kinase inhibitor | Also used for NSCLC with specific EGFR mutations. |
| Osimertinib (Tagrisso) | EGFR tyrosine kinase inhibitor, including T790M mutation | Used for NSCLC with EGFR mutations, including the T790M resistance mutation. |
Gefitinib Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Diarrhea | Interstitial lung disease (ILD) |
| Rash | Liver problems |
| Dry skin | Severe skin reactions (Stevens-Johnson syndrome, Toxic Epidermal Necrolysis) |
| Nausea | Corneal ulceration |
| Vomiting | Kidney problems |
Gefitinib Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Non-Small Cell Lung Cancer (NSCLC) | 250 mg | 250 mg once daily | Take at the same time each day, with or without food. |
Gefitinib Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $200 |
| Without Insurance (U.S.) | $1,500 |
| From Canada | $150 |
