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General Medication Fact Sheet for Gemifloxacin
| Field | Information |
|---|---|
| Generic Name | Gemifloxacin |
| Brand Name Versions | Factive |
| Boxed/Label Warning | Fluoroquinolones, including gemifloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart, or lung transplants. |
| Purpose | Antibiotic used to treat bacterial infections, primarily respiratory tract infections. |
| Mechanism of Action | Inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. |
| Dosage Forms | Oral tablets |
| Available Strengths | 320 mg |
| Dosage Frequency | Once daily |
| Common Side Effects | Nausea, diarrhea, headache, dizziness |
| Serious Side Effects | Tendon rupture, peripheral neuropathy, central nervous system effects (e.g., seizures), QT prolongation, liver damage, allergic reactions, *Clostridium difficile*-associated diarrhea. |
| Drug Interactions | Antacids containing aluminum or magnesium, iron supplements, calcium supplements, zinc supplements, sucralfate, warfarin, certain antiarrhythmic drugs, NSAIDs. |
| Important Notes | Avoid taking with antacids or supplements containing aluminum, magnesium, iron, calcium, or zinc. May increase sensitivity to sunlight. Contact your doctor if you experience muscle pain or weakness. Fluoroquinolones should be reserved for use in patients who have no alternative treatment options for uncomplicated urinary tract infections, acute bacterial exacerbation of chronic bronchitis, and acute bacterial sinusitis because the risk of serious adverse reactions generally outweighs the benefits for these patients. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. |
| Alternatives | Azithromycin, Levofloxacin, Moxifloxacin, Amoxicillin/Clavulanate. |
Gemifloxacin Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Azithromycin (Zithromax) | Macrolide antibiotic; inhibits bacterial protein synthesis. | Often used for respiratory infections; shorter course of treatment. |
| Levofloxacin (Levaquin) | Fluoroquinolone antibiotic; inhibits bacterial DNA gyrase and topoisomerase IV. | Similar mechanism to gemifloxacin, but different side effect profile. Reserve for when other options are not suitable. |
| Moxifloxacin (Avelox) | Fluoroquinolone antibiotic; inhibits bacterial DNA gyrase and topoisomerase IV. | Another fluoroquinolone option; reserve for when other options are not suitable. |
| Amoxicillin/Clavulanate (Augmentin) | Beta-lactam antibiotic; inhibits bacterial cell wall synthesis. | A penicillin-based antibiotic often used for respiratory and sinus infections. |
Gemifloxacin Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Tendon rupture |
| Diarrhea | Peripheral neuropathy (nerve damage) |
| Headache | Central nervous system effects (seizures, psychosis) |
| Dizziness | QT prolongation (heart rhythm issues) |
| Rash | Liver damage |
| *Clostridium difficile*-associated diarrhea | |
| Severe allergic reactions (anaphylaxis) |
Gemifloxacin Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Acute Bacterial Exacerbation of Chronic Bronchitis | 320 mg | 320 mg once daily | Take with or without food. Treatment duration: 5 days. |
| Community-Acquired Pneumonia | 320 mg | 320 mg once daily | Take with or without food. Treatment duration: 5-7 days. |
| Acute Bacterial Sinusitis | 320 mg | 320 mg once daily | Take with or without food. Treatment duration: 5 days. |
Gemifloxacin Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $25 |
| Without Insurance (U.S.) | $80 |
| From Canada | $40 |
