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General Medication Fact Sheet for Gengraf
| Field | Information |
|---|---|
| Medication Name | Gengraf |
| Generic Name | Cyclosporine |
| Boxed/Label Warning | May cause serious infections, lymphoma, and other malignancies; can cause hypertension and nephrotoxicity. |
| Purpose | Immunosuppressant used to prevent organ rejection in transplant patients and to treat certain autoimmune diseases. |
| Mechanism of Action | Inhibits T-cell activation by blocking the production of interleukin-2 (IL-2). |
| Dosage Forms | Oral capsules, oral solution |
| Available Strengths | 25 mg, 50 mg, 100 mg |
| Dosage Frequency | Typically twice daily, as directed by a healthcare provider. |
| Common Side Effects | Tremor, headache, hypertension, hirsutism, gingival hyperplasia, nausea, diarrhea. |
| Serious Side Effects | Nephrotoxicity, hepatotoxicity, seizures, infections, lymphoma, skin cancer. |
| Drug Interactions | Many drugs can interact with cyclosporine, including azole antifungals, macrolide antibiotics, calcium channel blockers, and grapefruit juice. |
| Important Notes | Regular blood tests are required to monitor drug levels and kidney function. Avoid grapefruit and grapefruit juice. |
| Storage | Store at room temperature away from moisture and light. |
| Missed Dose | Take as soon as you remember; if it is close to the time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose. |
| Alternatives | Tacrolimus (Prograf), Sirolimus (Rapamune), Mycophenolate mofetil (CellCept) |
Gengraf Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Tacrolimus (Prograf) | Calcineurin inhibitor; inhibits T-cell activation. | Similar to cyclosporine; often used in transplant patients. |
| Sirolimus (Rapamune) | mTOR inhibitor; inhibits T-cell proliferation. | Used in transplant patients to prevent organ rejection. |
| Mycophenolate mofetil (CellCept) | Inhibits purine synthesis, suppressing T- and B-cell proliferation. | Used to prevent organ rejection and treat autoimmune diseases. |
Gengraf Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Tremor | Nephrotoxicity (kidney damage) |
| Headache | Hepatotoxicity (liver damage) |
| Hypertension (high blood pressure) | Seizures |
| Hirsutism (excessive hair growth) | Infections |
| Gingival hyperplasia (gum overgrowth) | Lymphoma |
| Nausea | Skin cancer |
| Diarrhea | Posterior Reversible Encephalopathy Syndrome (PRES) |
Gengraf Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Kidney Transplant | 10-15 mg/kg/day | 2-6 mg/kg/day | Administer consistently with regard to meals. Blood level monitoring required. |
| Liver Transplant | 5-7 mg/kg/day | 2-6 mg/kg/day | Administer consistently with regard to meals. Blood level monitoring required. |
| Heart Transplant | 7 mg/kg/day | 2-6 mg/kg/day | Administer consistently with regard to meals. Blood level monitoring required. |
| Rheumatoid Arthritis | 2.5 mg/kg/day | Up to 4 mg/kg/day | Administer consistently with regard to meals. Blood level monitoring required. |
| Psoriasis | 2.5 mg/kg/day | Up to 4 mg/kg/day | Administer consistently with regard to meals. Blood level monitoring required. |
Gengraf Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 |
| Without Insurance (U.S.) | $100 |
| From Canada | $60 |
