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Gleevec (Imatinib)
| Imatinib Mesylate (Generic) Imatinib Mesylate | ||||||
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Shipped from Canada | ||||||
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| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
| Imatinib Mesylate (Generic) Imatinib Mesylate | ||||||
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Shipped from Mauritius | ||||||
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| Select product strength & quantity:
Who is the product for? YouOtherAdd Family Member/PetYou must be logged in to add additional members to the order. Don't have an account? or Add Family Member/PetSign inTo continue, please enter your email address and password that you use for your account. | ||||||
General Medication Fact Sheet for Gleevec
| Field | Information |
|---|---|
| Medication Name | Gleevec |
| Generic Name | Imatinib |
| Boxed/Label Warning | May cause fluid retention, severe congestive heart failure or left ventricular dysfunction, liver toxicity, and gastrointestinal hemorrhages. Monitor patients closely. |
| Purpose | Tyrosine kinase inhibitor used to treat certain types of leukemia (Chronic Myeloid Leukemia – CML) and other cancers. |
| Mechanism of Action | Inhibits the BCR-ABL tyrosine kinase, preventing the growth and spread of cancer cells. |
| Dosage Forms | Oral tablets |
| Available Strengths | 100 mg, 400 mg |
| Dosage Frequency | Usually once daily, or as directed by a healthcare provider. |
| Common Side Effects | Nausea, vomiting, diarrhea, muscle cramps, skin rash, fatigue. |
| Serious Side Effects | Fluid retention, edema, heart failure, liver toxicity, bleeding, myelosuppression (decreased blood cell counts), tumor lysis syndrome. |
| Drug Interactions | CYP3A4 inhibitors and inducers, anticoagulants (e.g., warfarin), acetaminophen, certain antibiotics (e.g., clarithromycin), certain antifungals (e.g., ketoconazole). |
| Important Notes | Take with food and a large glass of water to minimize stomach upset. Regular blood tests are necessary to monitor blood cell counts and liver function. Report any signs of bleeding, fluid retention, or infection to your doctor immediately. |
| Storage | Store at room temperature away from moisture and light. Keep out of reach of children. |
| Missed Dose | Take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose. |
| Alternatives | Tasigna (nilotinib), Sprycel (dasatinib), Bosulif (bosutinib) |
Gleevec Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Tasigna (nilotinib) | Tyrosine kinase inhibitor | Second-generation TKI; may have different side effect profile. |
| Sprycel (dasatinib) | Tyrosine kinase inhibitor | Second-generation TKI; may have different side effect profile. |
| Bosulif (bosutinib) | Tyrosine kinase inhibitor | Second-generation TKI; may have different side effect profile. |
Gleevec Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Fluid retention, edema |
| Vomiting | Heart failure |
| Diarrhea | Liver toxicity |
| Muscle cramps | Bleeding |
| Skin rash | Myelosuppression (decreased blood cell counts) |
| Fatigue | Tumor lysis syndrome |
Gleevec Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Chronic Myeloid Leukemia (CML) – Chronic Phase | 400 mg daily | 400 mg to 600 mg daily | Take with food and a large glass of water. |
| Chronic Myeloid Leukemia (CML) – Accelerated Phase or Blast Crisis | 600 mg daily | 600 mg to 800 mg daily | Take with food and a large glass of water. |
| Gastrointestinal Stromal Tumors (GIST) | 400 mg daily | 400 mg to 800 mg daily | Take with food and a large glass of water. |
Gleevec Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $100 |
| Without Insurance (U.S.) | $9500 |
| From Canada | $7500 |
