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General Medication Fact Sheet for Gleostine
| Field | Information |
|---|---|
| Medication Name | Gleostine |
| Generic Name | Lomustine |
| Boxed/Label Warning | Myelosuppression (bone marrow suppression) which can lead to serious or fatal infections and bleeding. Delayed myelosuppression can occur. |
| Purpose | Chemotherapy medication used to treat certain types of brain tumors and Hodgkin’s lymphoma. |
| Mechanism of Action | Alkylates DNA and RNA, inhibiting DNA and RNA synthesis, which interferes with cell division and causes cell death. |
| Dosage Forms | Oral capsules |
| Available Strengths | 5 mg, 10 mg, 40 mg |
| Dosage Frequency | Typically administered once every 6 weeks, or as directed by a healthcare provider. |
| Common Side Effects | Nausea, vomiting, hair loss, fatigue, loss of appetite. |
| Serious Side Effects | Myelosuppression (decreased white blood cells, red blood cells, and platelets), pulmonary toxicity (lung damage), liver damage, secondary malignancies. |
| Drug Interactions | May interact with other myelosuppressive agents, increasing the risk of bone marrow suppression. Use caution with other medications that affect liver or lung function. |
| Important Notes | Regular blood tests are necessary to monitor for myelosuppression. Report any signs of infection, bleeding, or breathing problems to your doctor immediately. |
| Storage | Store in a refrigerator between 36°F to 46°F (2°C to 8°C). Protect from light. |
| Missed Dose | Contact your healthcare provider immediately for instructions. Do not take an extra dose without consulting your doctor. |
| Alternatives | Temozolomide, Procarbazine, Carmustine, Vincristine |
Gleostine Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Temozolomide (Temodar) | Alkylating agent, methylates DNA | Used for the treatment of certain types of brain tumors. |
| Procarbazine (Matulane) | Monoamine oxidase inhibitor, inhibits DNA, RNA and protein synthesis | Used in the treatment of Hodgkin’s disease. |
| Carmustine (BiCNU) | Alkylating agent, forms DNA cross-links | Used for the treatment of brain tumors, multiple myeloma and Hodgkin’s lymphoma. |
| Vincristine (Marqibo) | Inhibits microtubule formation, disrupting cell division | Used in the treatment of Hodgkin’s lymphoma, leukemia and other cancers. |
Gleostine Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Nausea | Myelosuppression (decreased white blood cells, red blood cells, and platelets) |
| Vomiting | Pulmonary toxicity (lung damage) |
| Hair loss | Liver damage |
| Fatigue | Secondary malignancies |
| Loss of appetite | Infections |
Gleostine Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Brain Tumors | 130 mg/m² | 130 mg/m² every 6 weeks | Administered orally as a single dose. Dosage is based on body surface area. |
| Hodgkin’s Lymphoma | 100 mg/m² | 100 mg/m² every 6 weeks | Administered orally as a single dose. Dosage is based on body surface area. |
Gleostine Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $30 |
| Without Insurance (U.S.) | $1,200 |
| From Canada | $900 |
