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General Medication Fact Sheet for Gonal-F Solution
| Field | Information |
|---|---|
| Medication Name | Gonal-F Solution |
| Generic Name | Follitropin alfa |
| Purpose | Stimulates follicle development in women undergoing fertility treatment; stimulates sperm production in men. |
| Mechanism of Action | Recombinant follicle-stimulating hormone (rFSH) that binds to FSH receptors in the ovary or testes to stimulate gamete production. |
| Dosage Forms | Subcutaneous injection solution (pre-filled pen or vial) |
| Available Strengths | 300 IU, 450 IU, 900 IU per pen/vial |
| Dosage Frequency | Daily, as directed by a fertility specialist. |
| Common Side Effects | Headache, abdominal pain, nausea, ovarian hyperstimulation syndrome (OHSS, mild), injection site reactions. |
| Serious Side Effects | Ovarian hyperstimulation syndrome (OHSS, severe), multiple pregnancy, ectopic pregnancy, ovarian torsion, thromboembolic events. |
| Drug Interactions | Clomiphene citrate, other fertility medications; inform your doctor of all medications and supplements you are taking. |
| Important Notes | Use under the close supervision of a fertility specialist; monitor for signs of OHSS; proper injection technique is crucial. |
| Storage | Refrigerate unopened vials/pens; once opened, store as directed and use within the specified timeframe. |
| Missed Dose | Contact your doctor immediately for instructions; do not double the dose. |
| Alternatives | Menopur (menotropins), Clomid (clomiphene citrate), Letrozole (Femara). |
Gonal-F Solution Alternatives
| Medication | Mechanism of Action | Notes |
|---|---|---|
| Menopur (menotropins) | Contains both FSH and LH | May be used in women who need both FSH and LH stimulation. |
| Clomid (clomiphene citrate) | Selective estrogen receptor modulator (SERM) | Oral medication; stimulates ovulation by blocking estrogen receptors at the hypothalamus. |
| Letrozole (Femara) | Aromatase inhibitor | Oral medication; lowers estrogen levels to stimulate ovulation. |
Gonal-F Solution Side Effects
| Common Side Effects | Serious Side Effects |
|---|---|
| Headache | Ovarian hyperstimulation syndrome (OHSS, severe) |
| Abdominal pain | Multiple pregnancy |
| Nausea | Ectopic pregnancy |
| Injection site reactions | Ovarian torsion |
| Breast tenderness | Thromboembolic events (blood clots) |
Gonal-F Solution Dosage Guide
| Condition | Starting Dose | Maintenance Dose | Administration Notes |
|---|---|---|---|
| Ovulation Induction | As directed by physician | Adjusted based on ovarian response | Administered subcutaneously; typically starts early in menstrual cycle. |
| Assisted Reproductive Technology (ART) | As directed by physician | Adjusted based on ovarian response | Administered subcutaneously; often used in conjunction with other medications. |
| Male Infertility (spermatogenesis) | As directed by physician | Adjusted based on sperm count | Administered subcutaneously. |
Gonal-F Solution Price With And Without Insurance
| Purchase Context | Estimated Price |
|---|---|
| With Insurance | $50 – $200 |
| Without Insurance (U.S.) | $600 – $1200 |
| From CPS | $492 |
